This panel will provide a discussion on the options and opportunities for institutions and the biomedical research community to address issues related to regulatory/administrative burden. Under the auspices of the Federal Demonstration Project, the Compliance Unit Standard Procedure (CUSP) Project offers an option to address administrative burden at the institutional level. The goal of this project is to create a repository where participating institutions can share standard substances information and procedures used in animal care and use protocols with the broader animal welfare compliance community. The language contained in Section 2034 of the 21st Century Cures Act directs leadership of NIH, USDA, and the FDA to “complete a review of applicable regulations and policies for the care and use of laboratory animals and make revisions, as appropriate, to reduce administrative burden on investigators while maintaining the integrity and credibility of research findings and protection of research animals.” The review is to be completed within two years of the bill’s enactment. This bill provides the biomedical research community with a unique opportunity to have input into the process and, to that end, the Federation of American Societies for Experimental Biology (FASEB), the Association of American Medical Colleges (AAMC), and the Council on Governmental Relations (COGR), with the assistance of the National Association for Biomedical Research (NABR), prepared a report, in part, in response to the language in the 21 st Century Cures Act with recommendations on how to reduce the regulatory/administrative burden on animal care and use programs. This panel will consist of three presentations: an overview of the CUSP Project; an overview of the AAMC, FASEB, COGR, and NABR report; and an update on the work being done by the NIH, USDA, and FDA in response to the mandate in the 21st Century Cures Act.