Cellular and Physiological Nutrition/Metabolism

Nutritional Approaches to Mitochondrial Dysfunction, Sarcopenic Obesity and Aging

3:00 PM - 5:00 PM

Location: Ballroom C

Learning Objectives:


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Charles Brenner, PhD

Roy J Carver Chair & Head of Biochemistry
University of Iowa
Iowa City, Iowa

Charles Brenner is a graduate of Wesleyan University who trained in yeast molecular biology and genetics at Chiron Corporation and DNAX Research Institute before earning his PhD in cancer biology in the biochemistry department at Stanford. There, he purified and characterized Kex2 protease, the prototypical prohormone convertase. In 1993, he then moved to Brandeis to conduct his post-doctoral fellowship with Gregory Petsko in X-ray crystallography. He launched his independent laboratory at Thomas Jefferson University in 1996 on the histidine triad superfamily of nucleotide-binding proteins. Dr. Brenner was recruited to Dartmouth for leadership positions in the Norris Cotton Cancer Center in 2003. There, he made the seminal discovery of nicotinamide riboside (NR) as an unanticipated vitamin precursor of NAD and launched a program that fleshed out the NAD metabolome with discovery of new genes, enzymes, transporters, regulatory steps and quantitative methods. His group was the first to show that NR is a sirtuin activator, the first to develop quantitative targeted NAD metabolomics, and the first to conduct a clinical trial, which showed that NR safely elevates human NAD metabolism. Dr. Brenner was recruited to the University of Iowa in 2009 as the Roy J. Carver Chair and Head of Biochemistry, where he continues to run an active research group dedicated to mechanistic dissection of the ability of NR to protect against neuropathy, mitochondrial diseases and to improve maternal and neonatal health. He also serves as chief scientific adviser for ChromaDex, which has commercialized NR, and participates in clinical testing of NR in multiple diseases and conditions.


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Marcia C. Haigis, PhD

Associate Professor
Harvard Medical School
Boston, Massachusetts

Marcia C. Haigis obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 studying protein chemistry. She then performed postdoctoral research at MIT studying mitochondrial regulation and aging. Dr. Haigis is currently an Associate Professor in the Department of Cell Biology at Harvard Medical School. Her laboratory focuses on identifying new molecular regulation of mitochondria and understanding how these organelles adapt to cellular stress with an ultimate goal to understand how mitochondria contribute to aging and age-related diseases.


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Orian Shirihai, MD, PhD

Director, UCLA Metabolism Theme
UCLA David Geffen School of Medicine
Los Angeles, California


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Zhaoping Li, MD, PhD

Professor of Medicine, Director-Center for Human Nutrition, Chief-Division of Clinical Nutrition
David Geffen School of Medicine at UCLA
Los Angeles, Ca, California

Zhaoping Li, MD, PhD is the Director of the Center for Human Nutrition, Chief of the Division of Clinical Nutrition and Lynda and Stewart Resnick Endowed Chair in Human Nutrition at David Geffen School of Medicine at the UCLA. She is incoming President of National Board of Physician Nutrition Specialist, President of the World Association of Chinese Doctors in Clinical Nutrition, member of ASN Board of Directors.
Dr. Li is board certified in Internal Medicine and Physician Nutrition Specialist. She completed her MD and PhD in Physiology at Beijing University, China and has been a faculty member at UCLA. She is leading the Center for Human Nutrition to have vigorous research programs in nutrition, microbiome and metabolism; providing mentorship, didactic and informal training for young scientists, premed, medical students, medical residents, fellows and clinicians; directing clinical programs that specializes in metabolic diseases, bariatric medicine, gastrointestinal diseases and cancer prevention/treatment.
For nearly three decade Dr Li’s research interest has focused on translational research in the role of macronutrients, phytochemicals in the prevention and treatment of obesity related chronic diseases. She has been Principal Investigator for over 50 investigator-initiated NIH and industry- sponsored clinical trials and published over 150 peer-reviewed papers in journals such as JAMA, Annals of Internal Medicine, American Journal of Clinical Nutrition, and Journal of American Dietetic Association. She co-author the book “Primary Care Nutrition: Writing the Nutrition Prescription” that provides the necessary knowledge and tools to incorporate nutrition into primary care practice


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Bill Evans, PhD

Adjunct Professor of Medicine
Duke University Medical Center
Durham, North Carolina


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Nutritional Approaches to Mitochondrial Dysfunction, Sarcopenic Obesity and Aging

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