Cellular and Physiological Nutrition/Metabolism

Best Practices in Measuring and Reporting Blood Fatty Acids in Human Nutrition Studies

6/11/2018
10:30 AM - 12:00 PM

Location: 302

Learning Objectives:

Presentations:

J. Thomas Brenna, PhD

Professor, Pediatrics
University of Texas at Austin
Austin, Texas

Tom Brenna, PhD, was appointed in 2017 as Professor of Pediatrics, of Human Nutrition, and of Chemistry at the University of Texas at Austin, after 27 years as a Professor of Human Nutrition, and of Food Science at Cornell University in Ithaca, NY. His group’s basic research into the chemical, biochemical, metabolic, genetic and ecological aspects of fatty acids have had a decisive influence on modern knowledge of these key nutrients. His group discovered a specific polymorphism in fatty acid desaturase 2 (FADS2) that controls endogenous synthesis of long chain polyunsaturated fatty acids (LCPUFA) and drives human evolutionary adaptation. Their work has transformed our understanding of the LCPUFA biochemical pathways. In addition to being a Δ6-desaturase, his group showed that FADS2 is a Δ4-desaturase directly synthesizing omega-3 docosahexaenoic acid (DHA). They characterized how saturated palmitic acid (16:0) can compete for FADS2-mediated desaturation with PUFA substrates 18:2n-6 and 18:3n-3, a finding that suggests how excess de novo saturated fat synthesis may inhibit LCPUFA synthesis, thereby creating a demand for dietary LCPUFA. His group has contributed to the ecology and evolutionary aspects of LCPUFA, showing that omega-3 DHA nutrition limits growth in nestling tree swallows, and elements of the case for omega-3 nutrition in the evolution of the large human brain. More recently, his group has pioneered nutritional studies of branched chain fatty acids. They showed that branched fat-rich vernix caseosa, the first solid meal of humans, has a strong effect on development of nascent microbiota, and that branched fats are ubiquitous in the food supply. He is the fourth scientist to be honored with both ASN’s Osborne and Mendel Award for outstanding contributions to basic research in nutrition and the ASN’s Robert Herman Award for advancement of clinical nutrition (2013).

Presentation(s):

Send Email for J. Thomas Brenna

Melanie Plourde, PhD


Université de Sherbrooke
Sherbrooke, Quebec, Canada

Presentation(s):

Send Email for Melanie Plourde

Peter Jones, PhD

Director
Richardson Centre for Functional Foods and Nutrace
Winnipeg, Manitoba, Canada

Presentation(s):

Send Email for Peter Jones


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