Poster Topical Area: Dietary Bioactive Components
Location: Hall D
Poster Board Number: 259
Objective: The main aim of this study is to provide a systematic review examining the anti-diabetic impacts of different parts of Mangifera Indica Linn in the management of type 2 diabetes mellitus in-vitro and in-vivo. Natural products have long been and continue to be an attractive source of nutritious and pharmacological therapeutics. One such natural product is mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera Indica Linn.
Methods: The databases PubMed, FSTA, Web of Science and CINAHEL were searched using keywords diabetes* OR "diabetes mellitus" OR "type 2" OR "blood glucose" OR insulin* OR antidiabet*) AND (mango* OR "mangifera indica" OR "mangifera indica L"). Articles reviewed were published in English up to January 10.
Results: Twenty-five of 436 studies met the inclusion criteria. Exclusion criteria included review articles, non-specific mango-related plants, and articles which did not examine glycemic status. The articles that met the inclusion criteria included mangifera extracts obtained from Mangifera Indica Linn bark-stem (10.7%), peel (14.3%), flesh (17.9%), kernel (7.14%) and leaf (42.9%). Commercially available or provided mangiferin was used in 10.7% of the studies. Approximately 36% of the studies were in vitro and 78.6% were in vivo; 22.72% were human studies and 77.27% animal studies. The results confirm the anti-diabetic properties of Mangifera Indica Linn. Suggested hypoglycemic mechanisms of action included gene regulation of Glut 4, Irs 1, Pi3K and cell cycle genes, inhibition of alpha glucosidase, improved antioxidant statues, improved insulin sensitivity, and facilitated glucose uptake.
Conclusion: The mango extract, mangiferin was shown to have a potential role as a nutraceutical component for improving the hyperglycemia of type 2 diabetes. Presently inadequate studies support an anti-diabetic role for mango in humans. The efficacious findings in animal studies and in the human studies available indicate that an anti-diabetic role for Mangifera Indica Linn should be pursued further in human research.
Clemson, South Carolina