Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 52
Objectives: The purpose of this study was to evaluate the effect of red raspberry juice on bone mineral density and bone biomarkers in postmenopausal women with mild-to-moderate bone loss. Postmenopausal women are at an increased risk for chronic diseases including osteoporosis, cardiovascular disease, hypertension, and diabetes. Osteoporosis is a systemic skeletal disease characterized by an imbalance in bone remodeling that leads to decreased bone density, bone strength and an increasing risk for fracture. We hypothesized that daily consumption of whole red raspberry juice will maintain or increase lumbar spine bone mineral density (BMD) in postmenopausal women with mild to moderate osteopenia.
Methods: Using a double blind, randomized placebo controlled study design a total of 57 women were recruited and placed into two groups for a period of six months. The treatment group consisted of 30 participants consuming two ounces of red raspberry concentrate daily reconstituted with ten ounces water. The placebo group consisted of 27 participants consuming two ounces of a placebo mixture equivalent to the red raspberry juice concentrate in appearance, energy, and sugar content devoid of red raspberry. Dual energy x-ray absorptiometry (DXA) scans were performed at baseline and final visits to evaluate BMD. Serum and urinary samples were collected at baseline, midpoint and final visits to assess changes in bone markers.
Results: At the end of the study, total BMD decreased in the placebo group, but was maintained or slightly improved in the treatment group. Plasma levels of bone alkaline phosphatase (B-ALP), a marker of bone formation, decreased significantly in the placebo group from baseline to final; treatment group saw no significant changes. Deoxypyridinoline (DPD), a marker for bone resorption, decreased significantly in the raspberry group from baseline to final. In the placebo group the level of DPD decreased slightly from baseline to final but this change was not significant.
Conclusions: The findings of this study indicate that consumption of red raspberry for the 6 month duration resulted in positive impact on bone mineral density and overall bone health by decreasing bone resorption. Overall, the incorporation of red raspberries into the diet may help prevent bone loss.
Texas Woman's University