Poster Topical Area: Diet and Cancer
Poster Board Number: 224
Objectives: HIV and HCV infections may increase the risk for liver fibrosis, in part due to the direct effects of these viruses on the liver. FIB-4, a minimally invasive fibrosis assessment, is calculated using age, platelet count, AST, and ALT and has an acceptable sensitivity and accuracy for detecting liver fibrosis. The objective of this study was to examine the relationship between HIV viral load and FIB-4 in HIV/HCV co-infected and HIV mono-infected men and women in the MASH cohort.
Methods: Cross-sectional analyses from an observational longitudinal MASH cohort study were conducted. BMI was obtained by anthropometric measurements. HIV viral load was obtained from the participants' medical chart, blood was drawn for metabolic profile and platelet count. HBV infection was excluded. FIB-4 score was calculated: FIB-4= [(Age x AST)/ (Platelets x (sqr (ALT)]. We used Wilcoxon t tests and multiple regression analyses controlled for BMI, age and gender.
Results: There were 251 HIV infected (mean age 53.2 years±7.7 SD; 59% male; 65% Black), 85 HIV/HCV co-infected (mean age 53.1 years±9.34; 61% male; 57% Black), and 133 un-infected study participants (mean age 54.0 years±8.95 SD; 50% male; 59% Black). In the HIV/HCV co-infected group, FIB-4 score was higher than in the HIV mono-infected group (p<0.001) and the un-infected group (p<0.001). FIB-4 score was also higher in the HIV mono-infected group than the un-infected group (p=0.003). In the HIV/HCV co-infected group, a linear regression model showed HIV viral load was significatly related to higher FIB-4 scores (β=-1.615, SE=0.300, p<0.001). A similar relationship between detectable HIV viral load and higher FIB-4 was found in the HIV mono-infected group (β=-0.307, SE=0.109, p=0.005). In the HIV mono-infected group, this relationship held only for men (β=-0.317, SE=0.137, p=0.022), but not women (β=-0.278, SE=0.185, p=0.136), while there were no gender differences in the co-infected group (β=-0.016, SE=0.199, p=0.936).
Conclusions: Detectable HIV viral load is associated with more advanced liver fibrosis than when HIV viral load is undetectable or when patients are not infected. The differences between genders among HIV mono-infected participants warrant further investigation.
Florida International University