Poster Topical Area: Nutrition Translation

Location: Hall D

Poster Board Number: 619

P19-008 - Glycemic and Insulinemic Responses to Resistant Starch Type 4 under True-to-Life Testing Conditions

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Resistant starch (RS) has been shown to beneficially affect glucose homeostasis in the post-prandial period following carbohydrate (CHO) consumption. The primary purpose of the current study was to examine the differences in glucose and insulin responses between RS4 and native wheat starch (NWS) crackers when provided in standard amounts (50g available CHO) versus amounts that constitute standard serving sizes packaged for consumers.

Methods: Apparently healthy adults (n = 14; 20–38yrs) participated in this controlled randomized crossover trial. All participants completed five trials: 50g dextrose control drink (CON); crackers containing: 50g available CHO NWS (50NWS), 50g available CHO RS4 (50RS4), 35g by weight NWS (35NWS), and 35g by weight RS4 (35RS4). Participants fasted for 10–12hrs prior to each visit with a minimum 48hr washout period between trials. Blood glucose was measured via glucometer at baseline and 15, 30, 45, 60, 90, and 120mins post consumption. Insulin was measured via venous sample at baseline and 30, 60, and 120mins post consumption.

Results: Glucose incremental area under the curve (iAUC) was significantly lower for all cracker conditions when compared with CON (p < 0.001). When comparing percent differences between the 50g conditions (M ± SD; 78.25 ± 50.97%) with percent differences between the 35g conditions (66.39 ± 46.92%), there was not statistical significance (p = 0.43). There were no differences in glucose iAUC between any cracker conditions (p > 0.05). As compared to CON, insulin iAUC for 50NWS and 50NWS were not different (p > 0.99), but 35NWS and 35RS4 were significantly lower (p < 0.001). When comparing percent differences between the 50g conditions (29.06 ± 30.36%) with percent differences between the 35g conditions (88.29 ± 60.50%), differences between the 35g conditions were significantly larger (p < 0.02). The insulin iAUC responses were significantly lower for the 35g conditions as compared to the 50g conditions and also for the RS4 conditions as compared to the NWS conditions (ps < 0.01).

Conclusions: These results indicate differential metabolic responses, specifically a reduced post-prandial insulin response, for RS4 versus NWS crackers when using standard testing amounts as compared to more true-to-life serving sizes packaged for consumers.




Funding Source: MGP Ingredients Inc

CoAuthors: Mark Haub – Kansas State university; Ody Maningat – MGP Ingredients Inc.; Paul Sieb – Kansas State University; Sara Rosenkranz – Kansas State University

Trevor J. Steele


Kansas State University
Manhattan, Kansas