Poster Topical Area: Community and Public Health Nutrition
Poster Board Number: 56
Objectives: Gestational diabetes mellitus (GDM) is a serious problem that is increasing worldwide that post potential risk for severe complications for both mother and fetus. Epidemiological and interventional studies have linked the intake of tree nuts to reduced risk of diabetes in general population. We therefore assessed the effect of pistachios on postprandial glucose levels and incretin response in Chinese pregnant women with gestational impaired glucose tolerance (GIGT) or GDM.
Methods: Pregnant women met criteria for GIGT or GDM were randomly assigned to consume isocaloric whole-wheat bread or pistachio in a random sequence with 7 days washout in between. Blood glucose, insulin and incretin levels were measured at baseline and every 30 minutes up to 120 minutes.
Results: The glycemic response and the serum insulin levels to the two groups was both significantly lower at 30,60,90 and 120min after ingestion pistachios in comparison with whole-wheat bread(P<0.01). In GIGT group: the glucagon-like peptide-1(GLP-1) levels were higher after consuming pistachio than whole-wheat bread at 60 [5.07±4.66 vs. 3.30±2.67 pm] (P<0.05), 90 [5.53±4.75 vs. 2.88±2.37pm] (p <0.01), 120min [4.22±4.25 vs. 2.61±3.11pm] (p <0.05); the gastric inhibitory polypeptide (GIP) levels were lower after consuming pistachio than whole-wheat bread at 30 [29.15±42.04 vs. 43.93±47.82 pm], 60 [53.01±55.67 vs. 72.25±49.63 pm], 90[50.65±46.59 vs. 67.57±53.51pm], 120min[52.99±30.94 vs. 66.62±43.60 pm], but only at 120min the difference was statistically significant ( p <0.01). In GDM group: the GLP-1 levels were higher after consuming pistachio than whole-wheat bread at 90 [7.45±3.51 vs. 4.87±3.01pm] (p <0.01), 120 min [6.85±3.65 vs. 4.37±3.12pm](p <0.01); the GIP levels were lower after consuming pistachio than whole-wheat bread at 30 [23.26±22.26vs. 35.91±22.43 pm], 60min [44.93±27.89 vs. 63.92±32.10 pm] (p <0.05).
Conclusions: Compared with whole-wheat bread, pistachio consumption reduced postprandial glycemia, increased GLP -1 levels in both the GIGT group and the GDM group. These effects could be beneficial for pregnant women with GDM or GIGT.
Funding Source: This work was supported by American Pistachio Growers.
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Shanghai, Shanghai, China (People's Republic)