Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 673

P23-046 - Anti-inflammation effect of oral L. reuteri 263 supplementation in HED-derived obesity Rat

Sunday, Jun 10
8:00 AM – 6:00 PM

Obesity is a serious and costly issue to the medical welfare worldwide. Inflammation and high reactive oxygen species (ROS) are observed in obese targets, because obesity is a pro-inflammatory disease. Probiotics have been suggested as one of the candidates to resolve the obesity-associated problems, but how they combat obesity is not fully understood. Herein,we investigated the effects of Lactobacillus reuteri 263 (L. reuteri 263) on anti-obesity using four groups of Sprague Dawley rats (n=10/group), namely C (normal diet with vehicle treatment), HE (high-energy diet (HED) with vehicle treatment), 1X (HED with 2.1x109 CFU/kg/day of L. reuteri 263), and 5X (HED with 1.05x1010 CFU/kg/day of L. reuteri 263) for 8 weeks. During the experimental period, the average BW of the HE increased the most, while the BW of the 1X group was slightly higher than the 5X group.Plasma biochemistry was used to evaluate the effect of L. reuteri 263 on the health and anti-obesity of rats in current study. The HE group showed significantly higher levels of FBS, TG, TC, and LDL compared to the other groups, and was marginally higher than 1X for FFA. The HE group also had the lowest HDL compared to the other groups. The level of inflammatory factors, IL-6 and TNF-α, were 2 and 1.5 times higher in the HE group compared to the C group. The level of IL-6 was the highest in the HE group, while 1X and 5X groups also had significantly higher levels than in the control group In contrast, the level of antioxidant enzymes, SOD and GPx were increasing in L. reuteri 263 treatment groups. In the present study, we revealed that oral L. reuteri 263 supplementation significantly attenuated HED-derived obesity. L. reuteri 263 improved the characteristics of obesity, by decreasing pro-inflammation factors and increasing antioxidant enzymes in the serum.

CoAuthors: Ching-Hung Chan – Shih Chien University; Hui-Hsuan Ku – Shih Chien University

Hui-Yu Huang

Shih Chien University
Taipei, Taipei, Taiwan (Republic of China)