Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 474

P10-074 - Associations of plasma free amino acids with hyperuricemia in a 6-yr cohort study of Chinese men and women

Monday, Jun 11
8:00 AM – 3:00 PM

Objective:
Hyperuricemia is known as one of the risk factors for gout and cardiometabolic diseases. Certain amino acids play important role(s) in biosynthesis of purine and subsequent formation of uric acids. Different relationships between amino acid profiles and hyperuricemia or gout were reported by previous cross-sectional studies; however, evidence from prospective studies is limited. This study therefore aimed to investigate whether specific amino acid profiles are associated with the risk of hyperuricemia, as well as potential modifying factors in in a 6-yr Chinese cohort.

Methods:
Current study included 1,672 community-living Chinese men and women aged 50–70 years without baseline hyperuricemia. Baseline plasma amino acids were measured by gas chromatography-mass spectrometer. Incident hyperuricemia was defined as the occurrence of plasma uric acid ≥7.0 mg/dL for men or ≥6.0 mg/dL for women by the end of the 6 years follow-up. Logistic regression was applied to assess the associations of plasma amino acids with incident hyperuricemia, after adjustment for baseline risk factors. False discovery rate method was used to control for multiple testing.

Results:
The 6-yr incidence of hyperuricemia was 24.6%. Elevated cysteine and threonine were showed to be positively associated with increased incident hyperuricemia [Relative risk (RR) (95 % CI): 1.25 (1.15–1.36), P <0.001 and 1.13 (1.04–1.22, P=004) per 1 SD increment of cysteine and threonine, respectively] in both men and women, after multivariable adjustment. Notably, positively associations between phenylalanine and glutamine concentrations and incident hyperuricemia were only detected in men; while an inverse association between serine levels and incident hyperuricemia were only evidenced in women (all Pinteraction <0.05).

Conclusions:
In this prospective cohort study, we found escalated cysteine and threonine, mainly involving increased oxidative stress, were associated with higher incidence of hyperuricemia in both men and women. While sex-specific associations were observed in the case of phenylalanine and glutamine for men and serine, the precursor of uric acid, for women. It remains to be elucidated whether the specific amino acids could explode, at least partially, to the sexual differences on uric acid metabolism.




Funding Source:

This work was supported by the Ministry of Science and Technology of China [2016YFC1304903 and 2017YFC0909700]; the National Natural Science Foundation of China [81471013 and 81700700] and the Chinese Academy of Sciences [ZDBS-SSW-DQC-02].

CoAuthors: Feijie Wang – Institute for nutritional sciences; Chinese academy of sciences.; Liang Sun – Institute for nutritional sciences; Chinese academy of sciences.; Rong Zeng – Institute of biochemistry and cell biology; Chinese academy of sciences.

Xu Lin


Institute of nutritional sciences, Chinese Academy of Sciences
Shanghai, Shanghai, China (People's Republic)