Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 753

P20-021 - A Collaborative to Evaluate the Associations Among Biological, Social and Nutritional Status For Adolescent Women and their Babies Using Electronic Health Records Data

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: To build a multisite de-identified database of female adolescents, aged 12-21 years, and their subsequent offspring through 24 months of age from electronic health records (EHRs). To test the following hypotheses: 1) Obese adolescents will exhibit poorer health status and pregnancy outcomes when compared to non-obese adolescents; 2) Babies born to obese adolescents exhibit worse outcomes when compared to babies born to non-obese adolescents.

Methods: We created a community-academic partnership that included New York City Community Health Centers (n=4) and Hospitals (n=4), The Rockefeller University, The Sackler Institute for Nutrition Science and Clinical Directors Network (CDN). We used the Community-Engaged Research Navigation model to establish a multisite de-identified database extracted from electronic health records (EHRs) of female adolescents aged 12-21 years (January 2011 – December 2012) and their offspring through 24 months of age. These patients received their primary care between 2011 and 2015.

Results: The analysis included all female adolescents (n=122,556) and a subset of pregnant adolescents with offspring data available (n=2,917).Patients were mostly from the Bronx; 43% of all adolescent females were overweight (22%) or obese (21%) and showed higher systolic and diastolic blood pressure, blood glucose levels, hemoglobin A1c, total cholesterol, and triglycerides levels compared to normal-weight adolescent females (p<0.05). This analysis was also performed looking at the non-pregnant females and the pregnant females separately. There was a statistically significant association between the BMI status of mothers and infants' birth weight, with underweight/normal-weight mothers having more low birth weight (LBW) babies and overweight/obese mothers having more large babies.

Conclusion: This EHR database uses available measures from routine clinical care as a "rapid assay" to explore potential associations, and may be useful to detect the presence and direction of associations. This partnership has engaged community clinicians, laboratory and clinical investigators, and funders in study design and analysis, as demonstrated by the collaborative development and testing of hypotheses relevant to service delivery.

Funding Source: (1) The Sackler Center for Biomedicine and Nutrition Research at The Rockefeller University; (2) The Sackler Institute for Nutrition Science at The New York Academy of Sciences; (3) AHRQ 1-P30-HS-021667; (4) Patient-Centered Outcomes Research Institute (PCORI) R-1306-03961.

CoAuthors: Amanda Cheng, MPH – Clinical Directors Network, Inc; Caroline Jiang, MS – The Rockefeller University; Mireille Mclean, MPH – The New York Academy of Sciences; Peter Holt, MD – The Rockefeller University; Dena Moftah – Clinical Directors Network, Inc.; Rhonda Kost, MD – The Rockefeller University; Kimberly Vasquez, MPH – The Rockefeller University; Daryl Wieland, MD – Jacobi Medical Center/North Central Bronx Hospital ; Peter Bernstein, MD, MPH – Montefiore Medical Center; Siobhan Dolan, MD, MPH – Montefiore Medical Center; Mayer Sagy, MD – Morrisania Diagnostic and Treatment Center; Abbe Kirsch, CNM – Bronx Lebanon Hospital Center; Michael Zinaman, MD – Jacobi Medical Center/North Central Bronx Hospital ; Elizabeth DuBois, MSN, FNP-BC, AAHIVS – Community Healthcare Network; Barry Kohn, MD – NYU Lutheran Family Health Centers; William Pagano, MD, MPH – NYU Lutheran Family Health Centers; Gilles Bergeron, PhD – The New York Academy of Sciences; Stephanie Morgan, MS – Montefiore Medical Center; Judd Anderman, MA – Bronx Lebanon Hospital Center; Shwu Huoy Kwek, MBA – Community Healthcare Network; Julie Wilcox, MFA – Clinical Directors Network, Inc; Jan Breslow, MD – The Rockefeller University; Jonathan Tobin, PhD – Clinical Directors Network

Megan W. Bourassa

New York Academy of Sciences
New York, New York