Poster Topical Area: Nutrient-Gene Interactions
Location: Hall D
Poster Board Number: 444
Background: There is considerable debate surrounding the health benefit(s) of dietary supplements, particularly multivitamin/multimineral (MVM) supplements. Objective: The objective of this study was to determine the effect of MVM supplementation on indices of nutrition and antioxidant status, cardiovascular health, and to determine the effect of MVM supplementation on genome-wide gene expression in healthy adults.
Methods: 24 subjects (n=10 female) were enrolled in a double-blind, placebo controlled study for 4 weeks. Fasting blood samples were collected prior to and at the end of the study.
Results: Indices of nutrition status, including vitamins A, B6, B12, D, E and K were significantly increased following MVM supplementation. Additionally, two markers of cardiovascular health, HDL cholesterol and homocysteine, were significantly increased and decreased, respectively, while SOD activity was significantly increased in MVM supplemented individuals. Furthermore, we identified 97 genes (p
Conclusion: These data suggest that MVM supplementation can significantly improve numerous indices of human health. Moreover, MVM supplementation may modulate gene expression patterns in PBMC's in healthy humans, which may reflect gene expression patterns in other organs/tissues.
USANA Health Sciences
Salt Lake City, Utah