Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 257

E04-04 - Growth of healthy full-term infants fed with an infant formula containing different protein concentration and breast milk

Sunday, Jun 10
8:00 AM – 6:00 PM


The aim was to evaluate growth parameters in full term infants who received infant formula containning different protein concentrations compared with infants exclusively breastfeed during the first 4 months of life.


Healthy full-term infants (n=308) participated in a randomized, single blind, controlled trial. Of the 308 infants, a total of 96 were randomized to receive one of three infant formulas differing only in the amount of protein 1) Infants feed Low Protein Formula (IF-LP: 1.3g protein/dL) (n=18); 2) Infants feed a Very Low Protein Formula (IF-VLP: 1.0 g protein/dL) (n=16); and 3) Infants feed a Standard Protein Formula IF-SP: 1.5 protein/dL) (n=24). An additional group of Infants who received exclusively breastmilk (HM: 0.8-1.0 g protein/dL) (n=82). Weight, length and head circumference were evaluated at baseline, and every month for 4 months. Growth velocity included: weight gain (g/day), length (cm/month), and head circumference (cm/month), and was calculated considering rate of change from baseline to day 120. Weight-for-age z-score (WAZ), weight-for-length z-score (WLZ), length-for-age z-score (LAZ), head circumference‐for‐age z‐score (HCAZ) and body mass index-for-age z-score (BMIAZ) were calculated with WHO 2006 Child Growth Standard and compared with HM group by analysis of variance (ANOVA and ANCOVA) adjusted by initial value.


A total of 140 infants completed the study (45.5%). Mean age at baseline was 19.7 ±12.1 days. There were no significant differences among groups in adjusted changes in weight, length and head circumference after 4 months (table 1). There were no differences among groups in WLZ, LAZ, HCAZ and BMIAZ after 4 months. WAZ in breastfeed group were similar to infant formulas with different concentration of protein. Weight gain in breastfeed group and IF-VLP were similar and both were significantly lower than IF-LP and IF-CSP groups (table 2).


In conclusion, no difference in growth was found among the groups feed different protein concentrations in infants feed with infant formulas during the first 4 months of life. An infant formula containing 1.0 g of protein per dL promotes weight gain and normal growth in full-term infants similar to exclusively breast feed infants.

Funding Source: The project was funded by FOPER 2015 and CONACYT grant No. 199586.

CoAuthors: Olga Garcia Olga, PhD – Universidad Autonoma de Queretaro; Miguel Ángel Duarte-Vázquez , PhD – Nucitec S.A. de C.V. ; Dolores Ronquillo, Master – Universidad Autonoma de Queretaro; María del C Caamaño , Master – Universidad Autonoma de Queretaro; Carlos García-Ugalde, Master – Nucitec S.A de C.V.; Jorge L Rosado , PhD – Universidad Autonoma de Queretaro

Lorena Oropeza

Universidad Autonoma de Queretaro
Queretaro, Queretaro de Arteaga, Mexico