Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 810

P20-127 - Associations of Birth weight with adult weight status in the Framingham Generation 3 Cohort

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: Birth weight is hypothesized to influence the risk of obesity and other metabolic risk factors in adult life. This study investigates the association between birth weight and adult body mass index (BMI) using data from the longitudinal Framingham Heart Study Generation 3 Cohort (Gen3). 


Methods: Data were from 626 participants in the Gen3 cohort who were recruited from Framingham, Massachusetts in 2001 and began in-person medical exams in 2002-2004 (exam1). Adult BMI was measured at exam 1. Maternal-reported birth weight was obtained by matching information from mothers enrolled in the Framingham Heart Study-Offspring Cohort (FOS) to their adult offspring in Gen3. Multivariable linear regression estimated the association between maternal-reported birthweight and adult offspring BMI. Adult age, sex, smoking status, and physical activity were considered as covariates. 


Results: Maternal-reported birth weight was available for 303 men and 323 women in the Gen3 cohort. The average birth weight of the participants was 7.5 pounds (7.6 pounds for men and 7.4 pounds for women). At exam 1, the mean age of participants was 40.7 years (40.6 and 40.8 years among men and women, respectively). 55.1% were overweight or obese (BMI ≥ 25, 66.3% and 44.6% among men and women, respectively). There was a J-shaped relationship between birth weight and adult BMI (p for the quadratric term=0.013). After adjusting for covariates, adult BMI slightly decreased with increasing birth weight plateauing at ~6 to 8 pounds. Thereafter, adult BMI increased with increasing birth weight.


Our findings are consistent with previous literature, suggesting that birth weights exceeding 8 pounds are associated with higher BMI during adulthood and potentially greater risk of overweight and obesity. These data suggest that interventions during the prenatal period may have an influence on the metabolic health of adult offspring.

CoAuthors: Yong Lin – Rutgers School of Public Health; Jacqueline Litvak – New York University College of Global Public Health; Andrea Deierlein – New York University College of Global Public Health

Niyati Parekh

New York University College of Global Public Health
New York, New York