Poster Topical Area: Nutritional Epidemiology

Location: Hall D

Poster Board Number: 781

P20-083 - Furan-born risk and nutrients-born benefits in the diet of breast-feeding women in Korea

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Furan (F) has been classified as possibly carcinogenic (group 2B) by the International Agency for Research on Cancer. Exposure of the developing individuals is often secondary via placental transfer or through breast milk. Thus, F exposure from breast milk, food of lactating mother, and the general environment may be associated with further postnatal and development effects. In a recent Total Diet Study (TDS), mean exposure of the Korean adult population (AP) to F has been reported to be 0.201 μg/kg bw/day resulting in margin of exposure (MOE) of 4,766 based on the BMDL10 set by JECFA, the category of ‘possible concern’ in terms of risk assessment. Hence, we attempted to estimate dietary exposure of breast-feeding women (BW) to F while looking into major sources of F and some nutrients in their diet.

Methods: Utilizing the non-consecutive 2 days dietary intake data of 1,044 individuals collected through a Special Dietary Intake Survey on Vulnerable Population in 2011 through 2013 based on 24-recalls, a nationwide representative intake data set for BW was established. Based on F content in food samples prepared (cooked) in various ways from the aforementioned TDS, F exposure was estimated and food sources of F and some vitamins & minerals were identified.

Results: Mean F exposure of BW was estimated to be 0.160 μg/kg bw/day (exclusively breastfeeding women) and 0.129 μg/kg bw/day (partially breastfeeding women). With lower mean exposure compared with that in AP, corresponding MOE values were 6,000-7,442. The foods contributed to F exposure mostly in BW were breads, glutinous rice, soybean, imported beef, coffee, cookies, potato, soy sauce and tofu while noodles and beer were the top 2 contributors in AP. Although calcium, vitamin A and riboflavin intake adequacy is low (75-85% of RDA) in Korean BW, none of these foods turned out to be a significant source of any of these nutrients.

Conclusions: Altogether, in balancing F-born risk and nutrients-born benefits, avoiding those foods as much as possible during the period of breast-feeding could be an option to lower F exposure to MOE over 10,000 to facilitate a better health of breast-fed infants. Korean government is working on measures to lower F exposure.

Funding Source: This research was supported by a grant (13162MFDS049) from the Ministry of Food and Drug Safety in 2013-2018.

CoAuthors: Jee-Yeon Lee – Korea Health Industry Development Institute; Ari Choi – Korea Health Industry Development Institute; Do-Hee Kim – Korea Health Industry Development Institute; Miyong Yon – Korea Health Industry Development Institute; Seung-Ju Park – Korea Health Industry Development Institute; Haeng-shin Lee – Korea Health Industry Development Institute; Kwang Geun Lee – dongguk university; Sung-ok Kwon – Kangwon National University Hospital

Cho-il Kim

Invited Research Fellow
Korea Health Industry Development Institute
cheongju-si, Ch'ungch'ong-bukto, Republic of Korea