Poster Topical Area: Vitamins and Minerals
Location: Hall D
Poster Board Number: 529
Objectives: To evaluate associations between first trimester vitamin B6, folate and B12 concentrations and changes in total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride (TG) concentrations throughout pregnancy.
Methods: Blood samples from 178 pregnant women (20-40y), attending a public health care center in Rio de Janeiro/Brazil were collected during follow-ups at 5-13 (baseline), 20-26, and 30-36wk gestation. Plasma was analyzed for vitamin B6 (nmol/L) by high performance liquid chromatography-fluorescence detection, folate (nmol/L) and B12 (pmol/L) both via commercial Roche e411 bioanalyzer. Serum lipids were measured enzymatically, using commercial kits; LDL-c was calculated using the Friedewald formula. Adjusted longitudinal linear mixed-effects models were employed. Values of vitamins were fixed in the first trimester for the analyzes. Analyzes were adjusted for gestational weeks, age, education, smoking, alcohol, pre-pregnancy energy intake and early pregnancy body mass index.
Results: Prevalence of B6, folate and B12 adequacy were 94.8%, 99.4% and 81.5%. Mean concentrations (SD) of the in the first trimester were B6: 40.0nmol/L (18.2), folate: 27.0nmol/L (10.2), and B12: 320.6pmol/L (120.8). The mean concentrations (SD) of serum lipids in each trimester (1st, 2nd, 3rd) were TC: 160.6mg/dL (28.9), 210.6mg/dL(35.3), and 224.1mg/dL(41.4); LDL: 96.8mg/dL(21.6), 127.1mg/dL(28.7), and 137.6mg/dL(33.7); HDL: 47.8mg/dL(8.5), 57.1mg/dL(9.9), and 54.9mg/dL(10.0); TG: 79.9mg/dL(32.5), 130.3mg/dL(48.8), and 158.3mg/dL(48.9). In adjusted analyses, folate concentrations were associated with an increase in CT, LDL and TG throughout gestation (β 0.422, 95%CI 0.107-0.737, p=0.009; β 0.282, 95%CI 0.037-0.527, p=0.024; β 0.479, 95%CI 0.093-0.866, p=0.015; respectively), and B12 concentrations were associated with an increase in HDL (β 0.009, 95%CI 0.001-0.017, p=0.035).
Conclusions: Folate was associated with the increase of CT, LDL and TG during pregnancy, whereas B12 was associated with increase of HDL. No relationships were found between B6 and the lipids. There is a need for research to understand the associations of folate and B12 status and serum lipids changes in pregnancy.
Postgraduation Program in Nutrition and Food, Faculty of Nutrition, Federal University of Pelotas
Pelotas, Rio Grande do Sul, Brazil