Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 413

P13-156 - Associations between Maternal Consumption of Energy-Yielding Nutrients and Oligosaccharides in Milk Produced by Healthy, Breastfeeding Women

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives Recent studies indicate that both environment and genetics play roles in structuring human milk oligosaccharide (HMO) composition, and maternal nutritional status might be important in this regard. The primary goal of this investigation was to examine relationships between maternal consumption of energy-yielding nutrients and concentrations of HMO. Based on previous work (McGuire et al. 2017) suggesting relationships between maternal BMI or body weight and various HMO, we hypothesized that chronic maternal energy intake would be positively correlated with 2'-fucosyllactose (2'FL) and lacto-N-fucopentaose (LNFP) III, and negatively correlated with lacto-N-neotetraose (LNnT) and disialyllacto-N-tetraose (DSLNT). Methods Chronic maternal dietary intake was estimated via averaging values obtained from 24-hr diet recalls collected by 12 healthy breastfeeding women at 9 timepoints between d 2 and 6 mo postpartum. Similarly, HMO concentrations (analyzed by HPLC) were averaged across the same timepoints. Spearman rank correlations between dietary and HMO values were then calculated. Results Our data did not support the hypothesized associations between chronic energy intake and 2'FL, LNFP III, and DSLNT (rs = -0.27, 0.46, 0.42; P = 0.39, 0.13, 0.17, respectively). And contrary to our hypothesis, energy consumption was positively associated with LnNT (rs = 0.73; P = 0.007). Several other noteworthy associations were detected, including positive relationships between energy consumption and concentrations of lacto-N-tetraose (LNT), LNFP II, and LS-tetrasaccharide b (LSTb) (rs = 0.70, 0.64, 0.75; P = 0.01, 0.02, 0.004, respectively). Additionally, LNFP II concentration was positively associated with intakes of protein (rs = 0.83; P = 0.0007), various fatty acids (e.g., oleic acid, linolenic acid, and arachidonic acid; rs = 0.69, 0.65, 0.69; P = 0.01, 0.02, 0.02, respectively), and both mono- and poly-unsaturated fatty acids (rs = 0.84, 0.72; P = 0.005, 0.008, respectively). Conclusions These results provide preliminary evidence that maternal dietary intake may play a role in modulating HMO concentrations. Understanding the mechanisms whereby maternal diet influences HMO composition is important, as variation in HMO profile has been linked to infant health outcomes.



Funding Source:

Supported by the Bill & Melinda Gates Foundation, National Science Foundation grant IOS 1344288, and NIH grant P30 GM103324.

CoAuthors: Caroline Nissan – University of California, San Diego; Mara York – Washington State University; Sarah Brooker – University of Idaho; Lars Bode – University of California, San Diego; Mark McGuire – University of Idaho; Michelle McGuire – Washington State University

Janet E. Williams

Senior Research Scientist
University of Idaho
Moscow, Idaho