Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 323

P08-065 - Effects of Two Weeks of Daily Mango Fruit Intake on Vascular Function, Blood Pressure and Gut Fermentation in Healthy Adult Women

Monday, Jun 11
8:00 AM – 3:00 PM


Mangos are rich in mangiferin, a phenolic acid that has multiple bioactive effects. Combined with carotenoids, fiber and other nutrients, mangos may be of benefit to vascular health. This study assessed whether a short-term (14 days) or acute (2 h) intake of mangos can influence: 1) microvascular function and the augmentation index, determined by peripheral arterial tonometry; 2) blood pressure; 3) optical platelet aggregometry, and 4) gut fermentation, determined by breath hydrogen and methane, in healthy adult women.


25 healthy postmenopausal females (BMI 25-40 kg/m2) were assessed at 3 study visits. Study visit 1 (SV1) started a run-in period of 14 d during which no mangos were consumed, with baseline and 2 h measures taken. At study visit 2 (SV2), baseline (0 h) measures were taken, followed by ingestion of 300 gm (2 cups) of fresh, frozen mangos, and data were collected 2 h later. Participants then consumed 300 g of mangos daily for 14 d, followed by assessment at study visit 3 (SV3), which followed the same protocol as SV2. Breath samples were collected at baseline at each study visit.


A significant interaction between treatment and time (p=0.005) was observed for systolic blood pressure (SBP). At baseline, SBP was not significantly different between study visits, however SBP was significantly lower 2 h after mango intake during SV2 and SV3 compared to no mango intake during SV1 (112 ± 9 mmHg SV2 vs. 116 ± 12 SV1, P=0.013; 111 ± 11 mmHg SV3 vs. 116 ± 12 SV1, P=0.003). A significant treatment effect was noted for mean arterial pressure with mango intake compared to no mango intake (87 ± 7 mmHg SV2 vs. 89 ± 9 SV1, P=0.04; 86 ± 8 mmHg SV3 vs. 89 ± 9 SV1, P=0.005). Pulse pressure was significantly reduced 2 h post intake compared to baseline during SV2 (41 ± 7 mmHg baseline vs. 38 ± 5 2 h, P=0.005). Breath methane was significantly reduced in three of six participants that produced methane.


Two cups of mango intake had acute (2 h) beneficial effects on blood pressure in healthy postmenopausal women. A number of women showed favorable changes in breath methane, an indication of the potential influence of mango intake on gut fermentation.

Funding Source:

Supported in part by funds from the National Mango Board, Orlando, FL and USDA CRIS 2032 51530 02200D.

CoAuthors: Matthew Vanness – University of California, Davis; Roberta Holt – University of California, Davis; William Horn – Western Human Nutrition Research Center; Nancy Keim – Western Human Nutrition Research Center; Carl Keen – University of California, Davis; John Carson, MD – UC Davis; Robert Hackman – University of California, Davis

Xiang Li

Graduate student
UC Davis
Davis, California