Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 288

P13-030 - Calcitriol is Associated with Fe Status in Term Neonates

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Iron (Fe) deficiency and anemia at birth are detrimental to the neonate. The potential etiologies of anemia at birth are usually not identified or may be misclassified as Fe deficiency anemia (IDA) using the current cut-offs for Fe status indicators. Vitamin D deficiency also requires exploration since vitamin D status can impact erythropoiesis.The objective of this study was to examine interrelationships between Fe and vitamin D concentrations in neonates born to pregnant adolescents.


Methods:
A comprehensive panel of Fe status indicators, regulatory hormones, and vitamin D metabolites including hemoglobin (Hb), serum Fe, hepcidin, erythropoietin (EPO), calcium, calcitriol (1,25(OH)2D) and calcidiol (25(OH)D) were assessed in cord blood from 74 full term neonates (39.8 ± 1.2 weeks of gestation) born to adolescents in Rochester, NY.


Results:
The average cord Hb at birth was 14.19 ± 2.81g/dL; 23% of the neonates were anemic. Approximately 50% of neonates had 25(OH)D concentrations < 20nmol/L and 18% were < 12ng/mL. The average 1,25(OH)2D concentration was 44.73 ± 1.43pmol/L. There was no significant association between 25(OH)D and 1,25(OH)2D (p=0.78, n=71). Calcidiol was not significantly associated with Hb (p= 0.87), but 1,25(OH)2D was inversely associated with Hb status (p=0.0005, n=44). Calcitriol alone explained 25% of the observed variability in cord Hb (n= 44). Calcitriol appears to be associated with Fe status, as it was inversely associated with hepcidin (p< 0.0001, n=74), and serum Fe (p=0.005, n=71). Anemic neonates had significantly lower calcitriol (p<0.001) and hepcidin (p=0.02) concentration compared to non-anemic neonates.


Conclusion:
Neonatal calcitriol in cord serum explained a significant portion of the variation in Hb concentrations at birth and was associated with Hb and the Fe regulatory hormone hepcidin. Further analysis of these interrelationships is needed to better understand neonatal anemia and Fe deficiency to enable clinicians to try to prevent or ameliorate the risk of neurodevelopmental deficits.




Funding Source:

NIH (grant T32HD052471) and the USDA (grants 2005-35200 and 2008-01857)

CoAuthors: Ronnie Guillet – University of Rochester; Eva Pressman – University of Rochester; Ruth Anne Queenan – University of Rochester; Elizabeth Cooper – University of Rochester; Kimberly O'Brien – Cornell University

Katherine M. Delaney

Graduate Student
Cornell University
Ithaca, New York