Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 368

P13-110 - Factors associated with biomarkers of insulin resistance and increased concentration of insulin-like growth factor-1 in preterm infants

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective. To identify factors associated with biomarkers of insulin resistance (IR) and concentrations of insulin-like growth factor-1 (IGF-1) in preterm infants.
Methods. In a cross-sectional study, 80 infants, six months of age, with a history of prematurity who were born at the Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" were included, in the period from January to July 2016. Infants of either sex, apparently healthy, without underlying pathology or who had not been critically ill at birth; with birth weight ≥ 1000 g, gestational age ≥ 30 weeks, with the consent of their parents. Infants whose mothers reported chronic diseases and/or diseases related to pregnancy (eg, type 2 diabetes mellitus or gestational diabetes, eclampsia, etc.) were not included. Non-probabilistic sampling was performed, including consecutive cases that met the selection criteria. A questionnaire was performed on the parents; anthropometry parameters were measured and the serum values of lipid profile, glucose, insulin, and IGF-1 were determined. Statistical analysis. Descriptive statistics were performed and correlation analyzes between insulin, HOMA and IGF-1 levels with anthropometric and laboratory variables. Factors potentially associated with IR were compared between subjects with insulin, HOMA and IGF-1 values above the 90th percentile.
Results. Mean age 198.4 ± 53.5 days; 39 male, and 41 female. The frequency of deficit of weight for age was high (43%), as well as the deficit of length-for-age (33%). A positive correlation between insulin and HOMA index with values of birth weight and triceps skinfold was identified; and with laboratory parameters such as triglycerides, glucose and IGF-1.
Conclusions. Insulin resistance biomarkers are related to adiposity indicators in infants with a history of prematurity; probably the greatest gain of adipose tissue at this stage of life could be a risk factor for future metabolic alterations.




Funding Source: Consejo Nacional de Ciencia y Tecnología and Universidad de Guadalajara

CoAuthors: Alejandro Rios-Aguirre – Universidad de Guadalajara; Edgar Vasquez-Garibay – Universidad de Guadalajara; Liuba Aguirre-Salas – Hospital Civil de Guadalajara; Jose Farfan Covarrubias – Hospital Civil de Guadalajara

Enrique Romero-Velarde

Professor
Universidad de Guadalajara
Zapopan, Jalisco, Mexico