Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition
Location: Hall D
Poster Board Number: 279
Objectives: Parenteral nutrition associated liver disease (PNALD) and neonatal cholestasis are important morbidities in preterm infants. Fish oil based lipid emulsions were suggested to have an effect on prevention and/or reversal of neonatal cholestasis. Therefore, the aim of this prospective randomized trial was to compare the effects of soy-bean based oil and fish oil based lipid emulsions on prevention of neonatal cholestatis in very low birth weight (VLBW) infants.
Methods: A total of 170VLBW infants who were given total parenteral nutrition (TPN) ≥ 2 weeks were enrolled. Infants were randomized to two groups: 100% soy bean based lipid emulsion (S group) and 50% fish oil+50% soybean oil (F group). The demographical features, neonatal morbidities, duration of TPN, neonatal cholestatisis and associated laboratory data were all recorded.
Results: There were 88 and 82 infants in S and F groups, respectively The frequency of neonatal cholestasis were significantly lower in F group compared with S group. No PNALD was detected in fish oil group. Although there were no ststistically significant differences between 2 groups, the incidences of bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), and retinopathy of prematurity (ROP) were significantly higher in S group. Soybean based oil emulsion and duration of TPN were found to be sihnificantly associated with development of neonatal cholestasis in logistic regression analysis.
Conclusions: Fish oil based lipid emulsion significantly decreased the development of neonatal cholestasis. In addition, the incidences of severe BPD, NEC and ROP were significantly lower in fish oil group. We suggest that fish oil should be used safely and effectively for prevention of neonatal cholestasis in VLBW infants.
KanuniSultan Suleyman Training and Research Hospitaş
Istanbul, Istanbul, Turkey