Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 689

P23-062 - Daily Avocado Supplementation on Weight Loss via Hypocaloric Diet: A Prospective Randomized Trial

Sunday, Jun 10
8:00 AM – 6:00 PM

OBJECTIVES:
Obesity is known to increase risks of coronary heart disease (CHD), diabetes (T2D), and metabolic syndrome. Calorie controlled (hypocaloric) diets have been shown to reduce these risks by promoting safe and effective weight loss. Avocados are high in monounsaturated fat, dietary fiber, vitamin E and a variety of other phytonutrients; however there have been concerns about their calorie and fat content for inclusion in a weight loss diet. The objective of this study was to determine the effect of including one Hass avocado/day on weight loss and inflammatory/metabolic markers compared to consuming a hypocaloric diet only.

METHODS:
51 healthy adults were randomized to either a 12-week hypocaloric (500 cal deficit) diet that included one Hass avocado per day (AVO; n=24) or an equally hypocaloric diet without avocados (WL; n=27). Both groups received dietary instruction and counselling from a registered dietitian every other week. The primary endpoint was body weight. Secondary endpoints included changes in body composition, inflammatory markers (IL6, IL8, MCP-1, TNFα and IL1β) as well as metabolic markers (NGF, insulin, leptin and HGF). Circulating inflammatory and metabolic markers were analyzed using the multiplex human cytokine panel (Millipore).

RESULTS:
24 patients were randomized to the AVO intervention (age: 42.5 ± 2.6 years, 83% Female) and 27 patients to the WL group (age: 36.4 ± 2.1 years, 74% Female). Body weight, BMI and fat mass were reduced by 3.1%, 3.1% and 1.5% respectively in the WL group and 2.8%, 2.8%, and 0.8% in the AVO group. Reductions of serum levels of interleukin 6 (IL6) measured by the % change between week 0 and week 12 (Avo: -0.24 ± 0.25; WL: 0.37 ± 0.19; p = 0.05) and hepatic growth factor (HGF) (Avo: -21.36  ± 8.03; WL: 4.18 ± 7.39; p = 0.02) were significantly greater in the AVO compared with the WL group. Other inflammatory/metabolic markers were not changed significantly from baseline.

CONCLUSIONS:
In summary, including one avocado daily in a hypocaloric diet program does not affect weight loss and provides additional anti-inflammatory benefits. Investigations of potential changes in the microbiota are ongoing.




Funding Source: Research is supported by the Hass Avocado Board.

CoAuthors: Anna Rasmussen – UCLA Center for Human Nutrition; Shih Lung Woo, PhD, RD – UCLA Center for Human Nutrition; Shelby Yaceczko, RD – UCLA Center for Human Nutrition; Irene Gilbuena, LVN – UCLA Center for Human Nutrition; Gail Thames – UCLA Center for Human Nutrition; Paul Shao, Medical Student – UCLA; Alicia Yang, RD – UCLA Center for Human Nutrition; Susanne Henning, PhD, RD – UCLA Center for Human Nutrition; Jieping Yang, PhD – UCLA Center for Human Nutrition; David Heber, MD, PhD, FACP, FACN – UCLA Center for Human Nutrition; Zhaoping Li, MD, PhD – UCLA Center for Human Nutrition

Zhaoping Li

Professor of Medicine, Director-Center for Human Nutrition, Chief-Division of Clinical Nutrition
David Geffen School of Medicine at UCLA
Los Angeles, Ca, California

Zhaoping Li, MD, PhD is the Director of the Center for Human Nutrition, Chief of the Division of Clinical Nutrition and Lynda and Stewart Resnick Endowed Chair in Human Nutrition at David Geffen School of Medicine at the UCLA. She is incoming President of National Board of Physician Nutrition Specialist, President of the World Association of Chinese Doctors in Clinical Nutrition, member of ASN Board of Directors.
Dr. Li is board certified in Internal Medicine and Physician Nutrition Specialist. She completed her MD and PhD in Physiology at Beijing University, China and has been a faculty member at UCLA. She is leading the Center for Human Nutrition to have vigorous research programs in nutrition, microbiome and metabolism; providing mentorship, didactic and informal training for young scientists, premed, medical students, medical residents, fellows and clinicians; directing clinical programs that specializes in metabolic diseases, bariatric medicine, gastrointestinal diseases and cancer prevention/treatment.
For nearly three decade Dr Li’s research interest has focused on translational research in the role of macronutrients, phytochemicals in the prevention and treatment of obesity related chronic diseases. She has been Principal Investigator for over 50 investigator-initiated NIH and industry- sponsored clinical trials and published over 150 peer-reviewed papers in journals such as JAMA, Annals of Internal Medicine, American Journal of Clinical Nutrition, and Journal of American Dietetic Association. She co-author the book “Primary Care Nutrition: Writing the Nutrition Prescription” that provides the necessary knowledge and tools to incorporate nutrition into primary care practice