Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 733

P23-106 - Clinical Indicators of Sarcopenia in Normal Weight Obesity

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Normal weight obesity (NWO) is a relatively new diagnosis and is defined as normal BMI with increased body fat percentage (%). Even though these individuals are apparently healthy, they are at a higher risk of negative health outcomes. According past studies, physical inactivity is related to NWO, which may contribute to muscle loss and decreased muscle function. Sarcopenia is generalized loss of skeletal muscle mass and strength. We hypothesized that individuals with NWO have increased risk of sarcopenia.


Methods:
We conducted an exploratory, cross sectional study with 20 adults (Mean age = 32.2 years; SD = 10.4) with normal body mass index (BMI) of between 18.5 - 23 kg/m2 for Asians and between 18.5 - 25 kg/m2 for Caucasians. Height, weight, waist, hip, arm and calf circumferences were measured. Body fat and muscle mass were measured using Bioelectrical Impedance Analyzer. We categorized as NWO if total body fat% was above 23.1% and 33.3% for males and females, respectively (Romero-Corral A. et al). Grip strength was measured using a handgrip dynamometer (Lafayette) and the maximum value out of 6 readings from both hands was considered as the maximal grip strength. Anthropometric measurements were compared between NWL and NWO using general linear model.


Results:
After controlling for age (years), sex and ethnicity, total body fat mass was significantly higher (p=0.016) in NWO (18.80 kg; SE=1.20, n=8) than NWL (14.80 kg, SE=1.20, n=12). Lean mass was higher in NWL (47.95 kg, SE=1.7) than NWO (43.29 kg, SE=1.75, p=0.056). Maximal grip strength was also higher in NWL (41.04 kg: SE =1.86) than NWO (36.29 kg; SE= 1.94, p=0.077). We did not observe significant differences in other anthropometric measurements between the two groups when controlled for age, sex and ethnicity.

Conclusion. NWO may be associated with sarcopenia, since lean muscle mass and maximal grip strength are lower in NWO in our preliminary analysis. A future larger study to confirm this would be warranted.




Funding Source: Texas Tech University

CoAuthors: Kelcey Mumbower, BS – Texas Tech University, Lubbock, TX; Matt Short, MS – Texas Tech University, Lubbock, TX; Kim Youngdeok, PhD – Texas Tech University, Lubbock, TX; Emily Dhurandhar, PhD – Texas Tech University, Lubbock, TX

Nadeeja N. Wijayatunga

Postdoctoral Research Associate
Texas Tech University
Lubbock, Texas