Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 35
Objectives: Substitution of macronutrients may affect the risk of coronary heart disease (CHD) in different manners. Therefore, the aim of this study is to investigate the relationship of macronutrient intake and CHD, by taking into account single macronutrient subgroups and different substitutions, in a large prospective cohort study in the Netherlands.
Methods: This study was performed in 5,905 participants from The Rotterdam Study, a population-based cohort study. Macronutrient intake was measured with use of a semi-quantitative food frequency questionnaire (FFQ). Incidence of CHD was ascertained through medical records. Cox proportional hazard regression analyses were used to study the association between intakes of macronutrients and CHD incidence.
Results: In multivariable-adjusted models plant protein was inversely associated with incident CHD at the expense of animal protein (HR of 0.54; 95%CI 0.30 - 0.97) as well as at the expense of saturated fat (HR of 0.56; 95%CI 0.33 - 0.98). Furthermore, animal protein was related to an increased risk of incident CHD at the expense of plant protein (HR of 1.64; 95%CI 1.01 - 2.68). However, total protein intake showed no association with CHD. Carbohydrates, fat and their subgroups were not associated with CHD incidence at the expense of any other macronutrient.
Conclusion: Findings from this population-based prospective cohort study suggest that a higher plant protein intake at the expense of either animal protein or saturated fat is associated with a lower risk of CHD. These findings support the current guidelines that recommend a dietary pattern providing more plant-based and less animal-based food.
Funding Source: The work presented in this abstract was conducted within ErasmusAGE at the Department of Epidemiology of Erasmus Medical Center, Rotterdam, The Netherlands. ErasmusAGE is a center for aging research across the life course and is funded by Nestlé Nutrition (Nestec Ltd.) and Metagenics Inc. The funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript.
Erasmus University Medical Center
Rotterdam, Zuid-Holland, Netherlands