Poster Topical Area: Vitamins and Minerals
Location: Hall D
Poster Board Number: 520
Background: Breast cancer is the most common form of cancer diagnosed in Indian women. Objectives: The study was conducted with an objective to investigate the association between obesity and breast cancer and to assess the status of serum 25(OH)D levels among women diagnosed with breast cancer (BC). Methodology: A total of 200 women with BC attending a tertiary healthcare institute of Delhi, India matched with 200 healthy women for age (± 2 years) and socio economic status were included in the study. Data was collected on the background information including socio-demographic profile and educational status of the subjects using interviewer administered structured questionnaires. Anthropometric assessment was done to calculate body mass index (BMI) and waist to hip ratio (WHR). Non fasting blood samples (5 ml) were collected for the biochemical estimation of serum 25(OH)D and calcium levels by chemiluminescent immunoassay and colorimetric assay technique. Data was analyzed by univariable conditional logistic regression and significant variables with (p
Results: The mean age of patients at diagnosis of BC was 45 ± 10 years. Results of multivariable conditional logistic regression analysis revealed a significant association of high WHR and low serum 25(OH)D and calcium levels with risk of breast cancer. Women with high WHR had significantly higher odds of breast cancer with [OR (95% CI)] of [8.9 (4.1 - 19.5). A non significant association of BMI with breast cancer risk was observed. Women with low serum 25(OH)D and calcium levels had significantly higher odds of having breast cancer [3.1 (1.2 - 7.3)] and [5.6 (1.8 - 16.7)]. A protective effect of urban areas as place of residence against breast cancer risk was observed (p< 0.05). Vitamin D deficiency was observed in more than 80% of cases and controls. The deficiency was highly prevalent in cases with stage IV breast cancer as compared to patients with stage I breast cancer. However, no association was observed between serum 25(OH)D levels with stage of breast cancer.
Conclusion: The findings of the present study revealed a significant association of obesity reflected by higher WHR and not BMI in addition to low serum 25(OH)D and total calcium levels in women diagnosed with breast cancer.
Funding Source: Department of Biotechnology (DBT), New Delhi, India
Rajasthan, Rajasthan, India