Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition
Location: Hall D
Poster Board Number: 372
Objectives: To identify factors associated with the evolution of the anthropometric nutritional status in children with intestinal failure (IF) followed up at a center for intestinal rehabilitation.
Methods: in a prospective cohort study, children with IF receiving hospital and home parenteral nutrition, admitted between 2015 and 2017, were followed up during an 11 month-period (interquartile range 5.4/21.9 months) regarding growth and nutritional status. The most frequent cause of IF was necrotizing enterocolitis (55.5%). Anthropometric z scores of weight for age, height for age, body mass index for age, arm circumference, triceps skinfold and head circumference were collected at two-week intervals. Data were compared with WHO reference standards. The effect of the potential exposure variables (length of follow-up, gestational age, presence of intestinal failure associated liver dysfunction, necrotizing enterocolitis) on anthropometric z scores during the follow up period was analyzed using generalized estimating equations.
Results: A total of nine children (seven males and two females) with mean current age 18.2 (SD 11.1) months were included. Mean energy supply by parenteral nutrition was 72 (SD 18) kcal/kg/d. Eight patients were receiving enteral nutrition with a median energy intake (peptide-based or free amino formula) of 15.4 (interquartile range 1.7-31.0) kcal/kg/day. There were significant increases in anthropometric z scores of all anthropometric parameters during the follow-up. Median weight/age z score increased significantly from -4.13 to -1.39 (interquartile ranges: -4.99/-2.66 and -2.64/0.52 respectively) and height for age from -2.96 to -1.8 (interquartile ranges -5.67/-2.63 and -2.98/0.66 respectively). The frequency of malnutrition (based on weight for age) decreased from 100% to 33% by the last assessment. The length of follow-up was associated with increasing weight for age (coefficient: 0.12, 95% C.I.: 0.03/0.20; p=0.01) and height for age (coefficient: 0.14, 95% C.I.: 0.05/0.23; p=0.003).
Conclusions: There were significant increases in all anthropometric parameters. The length of follow-up was associated with increasing weight and height for age in children with IF during the follow-up period at the intestinal rehabilitation center.
São Caetano Do Sul, Sao Paulo, Brazil