Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 342

P13-084 - Immune status in early pregnancy is not associated with dietary protein, fibre or omega-3 polyunsaturated fatty acid intake in normal or overweight women.

Sunday, Jun 10
8:00 AM – 6:00 PM

OBJECTIVES: Pregnancy induces mild inflammation which when combined with the chronic inflammation associated with excess adiposity may exert a metabolic programming effect in utero. Evidence exists that diet (certain protein sources, fibre, and omega-3 polyunsaturated fatty acids (PUFA)) plays a role in the regulation of chronic inflammation. We aimed to explore whether dietary factors were associated with inflammation status in early pregnancy in normal and overweight women.

METHODS: The Be Healthy in Pregnancy Study (BHIP: NCT01689961) recruited healthy pregnant women in Hamilton, Burlington and London, Ontario, between 12-17 weeks gestation. Nutrient intake was estimated from 3-day food records using NutritionistProR (Version 5.2, Axxya Systems). Intakes were compared to the dietary reference intakes. CRP was measured by ELISA (Magnetic Luminex Assay, R&D Systems) in blood obtained at recruitment. Differences in dietary intakes between women with pre-gravid body mass index (pBMI) of normal weight (NW, 18.5-24.9kg/m2), overweight (OW, >25-29.9 kg/m2) and obese (OB, ≥30 kg/m2) groups were assessed by ANOVA. Associations between each dietary factor and CRP status were tested using multiple linear regression with pBMI and age included in the model.

RESULTS: In 227 pregnant women, baseline average protein intake (1.2±0.4 g/kg/day) exceeded the EAR and dietary fibre (24.0±8.6g/day) was lower than the AI. Protein source was predominantly dairy (23.0%) and meat (23.0%), compared to eggs and fish (8%), meat alternatives (6%), grains (16%), and fruits and vegetables (7%). OW/OB women had significantly lower average daily protein intakes compared to NW women (1.1/0.97 vs 1.4g/kg/day, p<0.001). Protein source, fibre and total omega-3 PUFA did not differ between NW, OW and OB groups, nor were they associated with circulating CRP in adjusted models (n=147).

CONCLUSIONS: Women across weight categories consume relatively similar protein sources, dietary fibre and omega-3 PUFA in early pregnancy, however OW/OB women consume significantly less total protein compared to NW women. These nutrients were not associated with systemic inflammation as measured by CRP, as has been shown in the non-pregnant population. Longitudinal assessments during pregnancy and post-partum of the relationship between these nutrients and other markers of inflammation is a next step. (Funded by CIHR)

Funding Source: Dairy Farmers of Canada, CIHR and DFC/AAFC Dairy Research Cluster; in-kind by GayLea Foods & Ultima Foods.

CoAuthors: Naomi Fink, PhD – McMaster University; Valerie Bertram, MSc – McMaster University; Michelle Mottola, PhD – Western University; Stephanie Atkinson, PhD, DSc (Hons) – McMaster University

Caroline J. Moore

Research Coordinator
McMaster University
Hamilton, Ontario, Canada