Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 72
OBJECTIVE: We hypothesized that individuals with low versus moderate/high baseline C-reactive protein (CRP) would have greater metabolic improvements in response to a dietary intervention.
METHODS: A randomized, 4 period, crossover, controlled feeding study was conducted with 31 individuals with overweight/obesity (30-70 y). Participants received four isocaloric, weight maintaining diets: (1) no treatment foods (average American diet [AAD], (2) 42.5 g/d of almonds (almond diet [ALD]), (3) 18 g/d of cocoa powder and 43 g/d of dark chocolate (chocolate diet [CHOC]), and (4) all 3 foods (CHOC+ALD). Cardiometabolc biomarkers were measured at baseline and after each diet period. Statistical analyses were performed using linear mixed models. Participants were grouped by low (n = 15) or moderate/high (n = 16) baseline CRP levels (< or ≥ 1.2 mg/L) for subgroup analyses.
RESULTS: There were no treatment effects for CRP. There were significant interaction effects between treatment and baseline CRP status for apolipoprotein B (ApoB) (P = 0.04), diastolic blood pressure (DBP) (P = 0.01), and lag time of LDL oxidation (P = 0.03). ApoB was significantly decreased from baseline after the AAD (-8.9 ± 3.7 mg/dL; P = 0.02), ALD (-11.9 ± 3.7 mg/dL; P = 0.003), and CHOC+ALD (-10.8 ± 3.7 mg/dL; P = 0.006) in individuals with a low baseline CRP; however, the level of ApoB did not change in those with a moderate/high baseline CRP (P > 0.05). In participants with a low baseline CRP, DBP was significantly decreased from baseline after AAD (-4.2 ± 1.6 mmHg; P = 0.01), ALD (-5.8 ± 1.6 mmHg; P = 0.001), and CHOC (-5.6 ± 1.6 mmHg; P = 0.001), whereas DBP did not change in those with a moderate/high baseline CRP (P > 0.05). Further, the lag time of LDL oxidation tended to increase after CHOC+ALD (P = 0.07) in participants with a low baseline CRP; there were no changes in the lag time of LDL oxidation in those with a moderate/high baseline CRP.
CONCLUSIONS: Our findings suggest that CRP modulated diet-induced metabolic changes; individuals with a low baseline CRP had improved lipids, vascular health, and oxidative stress in response to dietary intervention. These effects were not seen in those with a moderate to high baseline CRP. Baseline inflammatory status should be accounted for in diet intervention studies.
This study was funded by The Hershey Company and The Almond Board of California.
Pennsylvania State University