Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 417

P10-017 - Associations Between DASH Diet Score and Measures of Glycemia and Insulin Action in Obese Adolescents

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: The Dietary Approaches to Stop Hypertension (DASH) diet is a healthful dietary pattern that may reduce the risk of developing type 2 diabetes (T2D) in adolescents. We aim to determine the impact of adherence to the DASH diet on measures of glycemia and insulin action in obese adolescents.


Methods:
Baseline measures were obtained from an ongoing, randomized controlled intervention to prevent T2D in obese adolescents. The Technology Assisted Dietary Assessment system (TADA) was used to create a 4-day mobile food record. Glucose and insulin dynamics, including fasting and 2 hour glucose concentrations, homeostasis method assessment of insulin resistance (HOMA-IR), whole body insulin sensitivity index (WBISI), and dispositional index (DI) were assessed during a 2 hour oral glucose tolerance test (OGTT). DASH scores were calculated for each participant and separated into quintiles. Independent sample t-tests assessed differences between 1st and 5th DASH score quintiles and biomarkers from the OGTT. Values are expressed as mean ± standard deviation.


Results:
Obese adolescents were screened (n=22), composed of 9 boys and 13 girls, 50% had prediabetes. The body mass index of the participants was 34.6kg/m2. HbA1c concentrations were lower for participants who had DASH scores in the 5th quintile versus the 1st quintile, 5.12 ± 0.17 vs 5.42 ± 0.16 (p<0.05). A tendency for more favorable biomarkers was observed for fasting and 2-hour glucose concentrations, HOMA-IR, WBISI, and DI, but none were statistically significant.


Conclusions:
Adherence to the DASH dietary pattern may improve glycemia in adolescents. Prospective studies are needed to investigate this question. TADA is a useful tool for assessment of dietary intake in adolescents.




Funding Source:

Ralph W. and Grace M. Showalter Research Trust Grant, Purdue University

CoAuthors: Kendra Wilder – Purdue University; Lisa Smith – Indiana University; Carol Boushey – University of Hawaii Cancer Center; Edward Delp – Purdue University; Tamara Hannon – Indiana University; Nana Gletsu-Miller – Purdue University

Ethan M. Braun

Graduate Student
Purdue University
West Lafayette, Indiana