Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 417

P10-017 - Associations Between DASH Diet Score and Measures of Glycemia and Insulin Action in Obese Adolescents

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: The Dietary Approaches to Stop Hypertension (DASH) diet is a healthful dietary pattern that may reduce the risk of developing type 2 diabetes (T2D) in adolescents. We aim to determine the impact of adherence to the DASH diet on measures of glycemia and insulin action in obese adolescents.

Baseline measures were obtained from an ongoing, randomized controlled intervention to prevent T2D in obese adolescents. The Technology Assisted Dietary Assessment system (TADA) was used to create a 4-day mobile food record. Glucose and insulin dynamics, including fasting and 2 hour glucose concentrations, homeostasis method assessment of insulin resistance (HOMA-IR), whole body insulin sensitivity index (WBISI), and dispositional index (DI) were assessed during a 2 hour oral glucose tolerance test (OGTT). DASH scores were calculated for each participant and separated into quintiles. Independent sample t-tests assessed differences between 1st and 5th DASH score quintiles and biomarkers from the OGTT. Values are expressed as mean ± standard deviation.

Obese adolescents were screened (n=22), composed of 9 boys and 13 girls, 50% had prediabetes. The body mass index of the participants was 34.6kg/m2. HbA1c concentrations were lower for participants who had DASH scores in the 5th quintile versus the 1st quintile, 5.12 ± 0.17 vs 5.42 ± 0.16 (p<0.05). A tendency for more favorable biomarkers was observed for fasting and 2-hour glucose concentrations, HOMA-IR, WBISI, and DI, but none were statistically significant.

Adherence to the DASH dietary pattern may improve glycemia in adolescents. Prospective studies are needed to investigate this question. TADA is a useful tool for assessment of dietary intake in adolescents.

Funding Source:

Ralph W. and Grace M. Showalter Research Trust Grant, Purdue University

CoAuthors: Kendra Wilder – Purdue University; Lisa Smith – Indiana University; Carol Boushey – University of Hawaii Cancer Center; Edward Delp – Purdue University; Tamara Hannon – Indiana University; Nana Gletsu-Miller – Purdue University

Ethan M. Braun

Graduate Student
Purdue University
West Lafayette, Indiana