Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 102
Objectives: The prevalence of pre- and type II diabetes is increasing in the United States (U.S.). Although the influence of diet on the development of type II diabetes has been studied extensively, the effect of protein is less clear. Eggs are a rich source of important nutrients including protein, vitamins, minerals, carotenoids and lecithin. The objective of this study was to investigate the effect of egg consumption on factors associated with glycemic control and lipid profile in pre- and type-II diabetics.
Methods: In this 12-week, parallel, randomized controlled trial, 42 individuals between the ages of 40 and 75 years who were overweight or obese and had pre- and type II diabetes were included. Participants were randomly assigned to receive either one large egg per day (group A) or an equivalent amount of egg substitute for 12 weeks (group B/control). Serum and plasma samples were obtained to analyze lipid profile and biomarkers associated with glycemic control at baseline, 6- and 12-week time points. Body composition was assessed using dual energy x-ray absorptiometry (DXA).
Results: Regular egg consumption resulted in improvements of fasting blood glucose, which was significantly (P=0.05) reduced by 4.4% at the final visit in the egg group. Participants in the egg group had significantly (P=0.01) lower levels of homeostatic model assessment of insulin resistance (HOMA-IR) at all visits. Though the mean insulin level in the egg group was significantly lower at baseline and 6-week visits (P=0.01), these changes cannot be attributed to the treatment effects. Furthermore, in the egg group, ATP-binding cassette protein family A1 (ABCA1) was significantly higher at the 6-week visit (0.78±0.21 vs. 0.28±0.05 mg/dL, Pvs. 0.55±0.18 mg/dL, P=0.1). The mean Apolipoprotein A1 (Apo A1) level was also significantly higher at the final visit in the egg group compared to the control (147.43±5.34 vs 142.81±5.09 mg/dL, P=0.01). There were no significant changes in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels.
Conclusions: The findings of this study suggest that daily consumption of one large egg may reduce the risk of diabetes without having any adverse effects on lipid profiles in individuals with pre- and type II diabetes.
T32 Postdoctoral Fellow
University of Virginia, Division of Nephrology