Poster Topical Area: Diet and Cancer

Location: Auditorium

Poster Board Number: 221

P07-035 - Effects of Genistein on the Spontaneous Occurrence of Leiomyoma of the Oviduct in an Animal Model

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: Uterine leiomyomas (LM, myomas or fibroids) are the most common benign pelvic tumors in women with extremely high incidence. In this study, we investigated the effects of genistein supplementation on incidence and progression growth of spontaneously developing LM in an animal model as the chicken is the only nonhuman animal in which LM spontaneously develops with a high prevalence.


Methods:
Laying hens were randomized to three groups: control (no genistein, n = 100) or genistein supplementation (3.01, 52.48 and 106.26 mg/hen per day).


Results:
At the end of 180 weeks, genistein supplementation significantly reduced the number of leiomyomas as well as the size of the LM. Molecular analysis of the LM shown that genistein downregulated the expression of NF-κB and Bcl-2 whereas it upregulated Nrf2, HO-1 and Bax expression at protein level.


Conclusions:
Our results demonstrated that genistein supplementation leads to a significant and dose-dependent reduction in spontaneous LMs incidence and size by regulating NFkB and Nrf2 pathways in an animal model.




Funding Source: Turkish Academy of Sciences

CoAuthors: Cemal Orhan – Firat University; Engin Yenice – Poultry Research Institute, Ankara, Turkey; Mehmet Tuzcu – Firat University; Nurhan Sahin – Firat University; Ibrahim Ozercan – Firat University; Omer Kucuk – Emory University; Bulent Ozpolat – The University of Texas MD Anderson Cancer Center; Kazim Sahin – Firat University

Kazim Sahin

Professor
Firat University
Elazig, Elazig, Turkey