Poster Topical Area: Energy and Macronutrient Metabolism

Location: Hall D

Poster Board Number: 537

P10-138 - Foodomics Database: A New Tool for Estimating Molecular Profiles of Nutrient Intake during Precision Ketogenic Therapy

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Precision Ketogenic Therapy (PKT) is a high fat, low carbohydrate, adequate-protein diet that is prescribed using the macronutrient information on nutrition facts labels (NFL) of brand-name products. We created a foodomics database to estimate the molecular compounds (individual amino acids, fatty acids, and carbohydrates) of brand-name products and to evaluate patients' nutrient intake.


Methods:
The units of the molecular compounds in USDA SR 28 are converted from g/ 100 g of food to g/ 1 g of the macronutrient, resulting in the pattern of molecular compounds in corresponding macronutrients. Similar types of NFL products share the same base product calculated from the mean of nutrients of all related generic products. By using the amount of macronutrients listed on the NFL for different brand named products, and the base product, the amount of molecular compounds are listed in the foodomics database.

Daily dietary intake data of two patients (KG0232 and KG0222), who received PKT from 2015-2016, were used to examine whether this database could be used for documenting the amount of molecular compounds consumed.


Results:
The foodomics database was created for brand-name products using very recent NFL data from products collected in Florida and used to document the amount of molecular compounds consumed by patients (Table.1). Data from these two patients illustrate that use of the foodomics data permits researchers to address questions about whether tube fed and G-tube fed patients on PKT have a similar or different intake of:



Conclusions:
Researchers can use the foodomics database to estimate the amount of molecular compounds in different brand-name products and to estimate and document the molecular compounds in a patient's daily intake.



Funding Source:

Research reported in this publication was supported by the University of Florida Clinical and Translational Science Institute, which is supported in part by the NIH National Center for Advancing Translational Sciences under award number UL1TR001427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


University of Florida Foundation (KetoGator, Fund ID: 018555).


Table 1 Molecular compounds intake of patients who received PKT

CoAuthors: Peggy Borum – University of Florida

Lujia Yang

Graduate student
University of Florida
Gainesville, Florida