Poster Topical Area: Nutrient-Gene Interactions
Location: Hall D
Poster Board Number: 430
Objectives: Different taste perception may lead to distinctive food patterns that in turn may be related to obesity. Umami (pleasant savory), has been recognized as the "fifth taste". Some studies have associated umami substance with lower obesity risk. Some polymorphisms (SNPs) in candidate genes such as TAS1R1 and TAS1R3 (taste receptors type 1 member 1 and member 3) have been associated with umami perception with heterogeneous results. Moreover, genome-wide association studies (GWASs) for umami taste are very scarce. We aimed at analyzing the association between SNPs (n=11 in TAS1R1 and n=2 in TAS1R3) in candidate umami genes as well as at the GWAS level for umami taste perception as well as the association between a genetic risk score (GRS) of the main SNPs and obesity risk.
Methods: 356 participants in the PREDIMED PLUS-Valencia study were analyzed. Umami (monosodium l-glutamate, MSG, 200mM) taste was determined through laboratory tests on the perception of their intensity (score 0-5 ). Selected candidate SNPs were: TAS1R1 (rs10864625, rs11122094, rs11122096, rs11122100, rs11587438, rs12041318, rs12565181, rs34857011, rs4908563, rs4908923 and rs4908932) and TAS1R3 (rs34810828 and rs35424002). Genotyping was undertaken with the Human OmniExpress Illumina array (700K) and GWAS was carried out with PLINK (additive model). Top-ranked SNPs (P<0.00001) were identified and a weighted GRS with the independent SNPs (r2<0.2) was generated. Multivariate logistic regression was used for the association between the GRS and obesity risk.
Results: None of the SNPs (n=13) in the candidate genes was significantly associated with umami perception at P<0.05. We identified 14 GWAS-SNPs potentially associated with umami taste at P<0.00001. Non-related SNPs (n=8) were included in the GRS for umami taste. The GRS was strongly associated with umami taste perception and obesity risk, decreasing the risk when increasing the number of umami taste perception alleles (OR: 0.79; 95%CI:0.65-0.97; P=0.022, adjusted for age and sex).
Conclusions: We have detected new SNPs potentially associated with umami taste perception and a GRS of these SNPs is associated with decreased obesity risk.
Funding Source: CIBEROBN (ISCIII, Madrid, Spain), PI16/00366 (ISCIII, Madrid Spain), PROMETEO17/2017 (Generalitat Valenciana, Valencia, Spain), University Jaume I, Castellon, Spain (P1-1B2013-54 and COGRUP/2016/06).
Doctorate Student in the Dep. of Preventive Medicine, University of Valencia/CIBEROBN
Universitat Jaume I - University of Valencia/CIBEROBN
Castellón, Comunidad Valenciana, Spain