Poster Topical Area: Maternal, Perinatal and Pediatric Nutrition

Location: Hall D

Poster Board Number: 298

P13-040 - Association between vitamin D status in early pregnancy and gestational weight gain: A Prospective Cohort in Rio de Janeiro, Brazil.

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: To evaluate the association between vitamin D status in early pregnancy and body weight (BW) throughout pregnancy and total gestational weight gain (GWG).
Methods: A prospective cohort of 163 healthy pregnant women from Rio de Janeiro was followed between 5th-13th (baseline), 20th-26th and 30th-36th gestational weeks. Plasma 25-hydroxyvitamin D [25(OH)D] concentration was measured using liq­uid chromatography-tandem mass spectrometry and categorized as adequate (≥50nmol/L) or inadequate (<50nmol/L). Maternal BW was evaluated in each gestational trimester. GWG (kg) was calculated as the difference between weight measured prior to delivery and the weight measured at the baseline and classified as insufficient/adequate or excessive according to the Institute of Medicine. Statistical analyses were performed using longitudinal linear mixed-effects and logistic regression models. The confounders were selected based on a directed acyclic graph and the model was adjusted by gestational age, age, self-reported skin color, alcohol intake, smoking, education and daily energy intake during pregnancy.
Results: The prevalence of vitamin D inadequacy was16.6% in early pregnancy. The mean of BW in the first, second and third trimester was 63.3 (SD=11.9), 68.6 (SD=11.7) and 72.5 (SD=11.8) kg, respectively. The women had 30% of insufficient, 35% of adequate and 35% of excessive GWG. There was a longitudinal increase (β=4.49, 95%CI: 2.37; 6.60, p<0.001) in BW throughout pregnancy among women with vitamin D inadequacy at baseline in comparison to women with adequacy. Women with vitamin D inadequacy in early pregnancy also presented higher chances to have excessive total GWG (OR=2.61, 95%CI: 1.07; 6.36, p=0.035).
Conclusions: We found an inverse association between vitamin D status adequacy in early pregnancy and gestational BW and GWG.




Funding Source:

The Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State (FAPERJ)
The National Council for Scientific and Technological Development (CNPq)

CoAuthors: Thais Rangel – Rio de Janeiro Federal University ; Mônica Batalha – Rio de Janeiro Federal University ; Dayana Farias – Rio de Janeiro Federal University ; Erica Barros – Rio de Janeiro Federal University ; Aline Ferreira – Rio de Janeiro Federal University ; Michael Holick – Boston University; Rana Mokhtar – Boston University; Gilberto Kac – Rio de Janeiro Federal University

Amanda C. CUNHA.. Figueiredo

PhD student
Rio de Janeiro Federal University
Rio De Janeiro, Rio de Janeiro, Brazil