Poster Topical Area: Dietary Bioactive Components
Location: Hall D
Poster Board Number: 305
Objectives: The potential effects of ginger (Zingiber officinale), a root vegetable, on prevention of obesity is well-known. Root vegetables are reported to change the chemical profiles and bioactivities by steaming or heating process. In the present study, the anti-obesity effects of ethanolic extract of steamed ginger in diet-induced obese mice were investigated.
Methods: Male C57BL/6J mice were fed a normal diet (ND, 10% fat w/w), high-fat diet (HFD, 60% fat w/w, n=10), HFD supplemented with either 40 mg/kg or 80 mg/kg of GSE (GHFD4 or GHFD8, respectively) for 12 weeks (10 mice/group). Serum lipids, glucose, insulin, adiponectin, and leptin were measured. The expression of genes involved in adipogenesis and lipid metabolism were measured in epididymal adipose tissue. Histological analysis of adipose tissue was performed.
Results: HFD significantly increased the body weight, liver and epididymal adipose tissue weights compared with ND control, whereas GSE supplementation attenuated the increases by HFD. The increases in serum total cholesterol, low-density lipoprotein cholesterol, triglyceride, glucose, insulin by HFD were significantly decreased in GHFD4 and GHFD8. The mRNA expression of adipogenesis and lipid metabolism related genes were significantly altered by HFD. However, GSE significantly decreased the expression of genes for adipogenesis and lipogenesis such as peroxisome proliferator-activated receptor γ, CCAAT-enhancer-binding proteins, aP2, sterol regulatory element-binding protein 2, fatty acid synthase and acyl-coA carboxylase in epididymal adipose tissue. Moreover, the size and the number of adipocytes were significantly decreased in adipose tissue of GHFD4 and GHFD8 compared to those of HFD.
Conclusions: The present study provides that ethanolic extract of ginger have anti-obesity potential by decreasing the adipose tissue size with the regulation of adipogenesis and lipid metabolism related genes in the epididymal adipose tissue of diet-induced obese mice.
Department of Food Science and Human Nutrition, Chonbuk National University
Jeonju, Cholla-bukto, Republic of Korea