Poster Topical Area: Neurobiology

Location: Hall D

Poster Board Number: 705

P16-003 - Imbalanced one-carbon donor nutrient metabolism in the progression of cognitive dysfunction: a human cross-sectional study

Monday, Jun 11
8:00 AM – 3:00 PM

Epidemiologic studies have suggested that one-carbon donor nutrients associated with a significantly reduced risk of Alzheimer’s disease (AD). Then involved in synaptogenesis and DNA methylation, for example, folate, choline and betaine. If lack of these nutrition may improve mild cognitive impairment (MCI) to develop into AD. Several studies have provided data on nutritional status in AD and MCI, but for one-carbon nutrients results inconclusive. Aims of the study are investigate imbalanced one-carbon donor nutrient metabolism in the progression of cognitive dysfunction. Subjects probable AD, MCI and control was recruited form the Department of Neurosurgery at National Taiwan University Hospital. One-carbon nutrient study of assay by the general questionnaire, cognitive function test, semi-quantitative food frequency questionnaire and fasting blood collection. We analyzed diet questionnaires, genotype and blood levels of Aβ, Tau, homocysteine, folate, choline and betaine. Results showed that the older the more serious of the disease (P<0.05). In nutrition of deficiency rate analysis of three groups, we found total kilocalorie, protein, folate, betaine and male choline have lower intake (P<0.05) in MCI group. Nutritional stratification found choline intake was significantly decreased (P<0.05) in MCI group. Correlation between one-carbon nutrient and homocysteine will be analysis. Since there is no exact and effective treatment in clinical. In future, maybe we can early detection nutrition status for early treatment.


CoAuthors: Chen Da-Fu – National Taiwan University Hospital; Hsu Hong-Zheng – National Taiwan University Hospital; Huang S. Rwei-Fen – Fu Jen Catholic University

Wang Bei-Wen

Fu Jen Catholic University
New Taipei, New Taipei, Taiwan (Republic of China)