Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 643

P23-016 - Effects of onion on body fat accumulation and browning of white adipose tissue in ovariectomized mice fed with a high fat diet

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Menopause is always associated with overweight and obesity, especially abdominal fat accumulation, leading to increase risks of various metabolic disorders. This study examined the effects of onion on menopause- and obesity-associated factors in ovariectomized (OVX) mice fed with a high fat diet. Browning and lipid metabolism of abdominal white adipose tissue were also determined.


Methods: Forty female C57BL/6 mice fed with a high fat diet (containing 53% fat) were randomly assigned into four groups, sham, OVX, OVX with 5% onion diet, and OVX with 0.1% S-methyl-l-cysteine (SMC) drinking water. The animals were subjected to a CT Scan for measuring the distribution of white adipose tissue (WAT), and then were sacrificed after 16 weeks of treatment. Blood and tissues were collected for determining menopause- and obesity-associated markers.


Results: OVX significantly induced menopause phenomena, including decreased uterus weight and serum estrogen concentration, as well as increased body weight for the first 10 wk after OVX, although the body weight was similar to the sham group at the end of the experiment. Onion consumption significantly increased body weight, but not the total body fat, throughout the experimental period. Furthermore, onion significantly decreased abdominopelvic WAT content, and with a tendency to increase the expression of adipocyte browning markers, PGC-1α and UCP1 in abdominopelvic WAT, indicating that onion had a potential to induce WAT browning. SMC, one of the bioactive components in onion, showed no such effects.


Conclusions: Although onion increased body weight of OVX mice fed with a high-fat diet, it did not increase total body fat contents, and even decreased abdominal fat accumulation. Such effects may be partially associated with the increased expression of adipocyte browning factors, PGC-1α and UCP1.




Funding Source:

Ministry of Science and Technology: MOST 105-2320-B-038 -035 -MY3


CoAuthors: Chia-Ying Wu – Taipei Medical University

Yue-Hwa Chen

Professor
Taipei Medical University
Taipei, Taipei, Taiwan (Republic of China)