Poster Topical Area: Nutritional Epidemiology
Location: Hall D
Poster Board Number: 817
Objectives: Vitamin D is hypothesized to prevent periodontal disease through its immune modulatory mechanisms and its role in calcium homeostasis. Few studies have investigated the association of vitamin D status and local oral inflammation. Our objective was to examine the cross-sectional association between vitamin D status and biomarkers of oral inflammation among post-menopausal women.
Methods: We analyzed data from 710 post-menopausal women who participated in the baseline Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study (1997-2000), an ancillary study to the Women’s Health Initiative (WHI) Observational Study. Multivariable linear regression was used to examine the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and markers of oral inflammation in saliva (Matrix Metalloprotinease-8 [MMP-8], Monocyte-Chemoattractant Protein-1 [MPC-1], Tumor Necrosis Factor-α [TNF-α], and C-Reactive Protein [CRP]), assessed using multiplex immunoassays. Salivary proteins were log-transformed for normality. Censored data methods were used for concentrations above and below the limits of detection. Multivariable models were adjusted for potential confounders.
Results: Thirty-five percent of women had deficient or inadequate vitamin D status (25[OH]D < 50 nmol/L). After adjustment for age, race, hormone use, frequency of brushing, and days since last dental visit, a significant inverse association was observed between 25(OH)D and CRP (7.3% lower CRP per 10nmol/L, 95% confidence interval [CI] 1.8 to 12.5, p=0.01). Further adjustment for body mass index, waist circumference, and recreational physical activity, strong predictors of 25(OH)D, attenuated this association (-3.3%, 95% CI -8.7 to 2.6, p=0.271). Similar inverse associations with 25(OH)D were observed for MMP-8, MCP-1, and TNF-α; however, they were not statistically significant.
Conclusion: Vitamin D may be associated with markers of oral inflammation. The roles of adiposity and physical activity need to be further understood.
University at Buffalo
Buffalo, New York