Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 341

P08-083 - Amylopectin/Chromium Complex (ACr; Velositol®): Liver and Kidney Function Safety Data

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Prior research has shown that when added to whey protein (WP), an amylopectin/chromium complex (ACr; Velositol®) significantly enhances muscle protein synthesis (MPS) in human skeletal muscle1. This preclinical study was conducted to evaluate MPS in rats administered different forms of protein, with and without Velositol. Because high protein diets have been associated with the potential risk for impairing liver and kidney function2, blood samples from this preclinical study were analyzed to evaluate Velositol's effects on liver and kidney function.


Methods: Male Wistar rats (8-week old) were assigned to a Control group, or one of several protein groups (8 rats/group). Rats received: WP (0.465, 1.55, 2.33, or 3.1 g/kg BW; a 6, 20, 30, or 40 g human dose equivalent (HED)), BCAA (0.465 g/kg BW; a 6 g HED), or pea protein (0.465 g/kg BW; a 6 g HED) with or without Velositol (1.55 g/kg BW; a 2 g HED). As part of the MPS study, all rats were exercised using a treadmill for 10 days, pretreatment. On the day of the single-dose experiment, rats were exercised at 26 m/min for 2 hours and then fed their assigned study product via oral gavage immediately after exercise. One hour later, the animals were sacrificed, and blood samples were taken to analyze markers of liver and kidney function (AST, ALT, and CREA).


Results: Study results show that compared to the protein alone groups, there were no substantial changes in AST, ALT, or CREA levels in the Velositol plus protein groups. However, there was a slightly larger decrease in AST levels, indicating improved liver function, in the Velositol plus protein groups compared to the protein alone groups (Figure 1).


Conclusions: In this preclinical study, Velositol did not show any detrimental effects on liver and kidney function when added to various sources and doses of protein. Rather, a greater decrease was seen in AST levels in Velositol plus protein groups, suggesting that Velositol intake with protein after exercise promotes healthy liver function. This study provides additional data supporting the safe use of Velositol in individuals consuming higher levels of protein, enabling them to gain strength while also maintaining liver and kidney health.



Funding Source: This study was funded by Nutrition 21, LLC
Figure 1.

CoAuthors: Kazim Sahin – Firat University; Sarah Sylla – Nutrition 21, LLC; James Komorowski – Nutrition 21, LLC

Sara Perez Ojalvo

Sr. Manager, Scientific Affairs
Nutrition 21, LLC
Purchase, New York