Poster Topical Area: Obesity

Location: Hall D

Poster Board Number: 659

P23-032 - Anthropometric, body composition and metabolic changes following a supervised dietary weight loss intervention in women with obesity

Sunday, Jun 10
8:00 AM – 6:00 PM

OBJECTIVE: The aim of this study was to assess anthropometric, body composition and metabolic changes in women with obesity who participated in a supervised inpatient weight loss intervention for 2 weeks.

METHODS: Participants were twenty five women aged 20 to 40 years, and with obesity (BMI, 30 to 35 kg/m2); they were required to be free from hypertension or diabetes, have been weight stable in the 3 months prior to enrolment and available for the inpatient period of the study. The intervention was conducted in a well-controlled inpatient setting, at the Metabolic Unit of Ribeirão Preto Medical School's Clinical Hospital, University of São Paulo. Subjects received two weeks of a hypocaloric diet with a 30% reduction in energy intake. Total energy needs were estimated using indirect calorimetry measured resting energy expenditure (REE), a 10% estimate for the thermic effect of food, reported level of physical activity and age. Food intake was evaluated using 4-day food diaries that subjects completed at home the week prior to the weight loss intervention. Body composition was determined by bioelectrical impedance analyses and all measures were obtained at baseline and at the end of the two week intervention. Paired t-tests were used to compare anthropometric, body composition and REE before and after the intervention, and a value of P˂0.05 was used to denote statistical significance. This trial is registered at clinicaltrials.gov (NCT02953353).

RESULTS: Average age (Mean±SD) was 32±5 years. Significant decreases from baseline were observed following the 2 week supervised intervention for: body weight (85±8 kg vs. 83±7 kg), BMI (33±1 kg/m2 vs. 32±1 kg/m2), waist circumference (107±6 cm vs. 105±6 cm), fat free mass (52±4 kg vs. 51±4 kg) fat mass (33±4 kg vs. 32±4 kg) and REE (1556±152 kcal vs. 1459±148 kcal), (P

CONCLUSIONS: Our intervention, based on a 30% reduction in total energy needs and total adherence, was effective in promoting a reduction of approximately 3% of body weight over a period of two weeks. Since adherence to weight loss interventions is challenging achieving clinically meaningful weight loss may require the provision of a shorter-term supervised weight loss intervention.




Funding Source:

FAPESP (2016/04766-6 and 2016/10785-3)
FAEPA

CoAuthors: Sai Das – 2Energy Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA; Vivian Suen – Ribeirao Preto Medical School University of Sao Paulo; Greta Magerowski – 3Laboratory of Bariatric and Nutritional Neuroscience, Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Isabela Rozatte Silva – Ribeirao Preto Medical School University of Sao Paulo; Rafaella Ribeiro Salgueiro – Ribeirao Preto Medical School Sao Paulo University; Cassia Dias Machado – Ribeirao Preto Medical School Sao Paulo University; Julio Marchini – Ribeirao Preto Medical School Univesity of Sao Paulo; Miguel Alonso-Alonso – 3Laboratory of Bariatric and Nutritional Neuroscience, Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Priscila GIACOMO.. Fassini

Professor
Ribeirao Preto Medical School
Ribeirão Preto, Sao Paulo, Brazil