Poster Topical Area: Nutritional Immunology
Location: Hall D
Poster Board Number: 841
Objective: This study aimed to investigate the association between the Brazilian Health Eating Index (BHEI) and plasma inflammatory biomarkers in the cross-sectional population-based study, Health Survey of Sao Paulo (HS-SP).
Methods: The study sample includes all 20 to 59 years old individuals, whose dietary, socioeconomic, lifestyle, and anthropometric data, as well as blood samples were collected as part of the HS-SP conducted during 2008-2010. Dietary data was collected using two non-consecutive 24-hour recalls and adjustments for within-person variation of intake were addressed using the Multiple Source Method. The BHEI was calculated according to standard protocols. Plasma C-reactive protein (CRP), adiponectin, tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1β, IL-8, IL-12, IL-10, Chemokine C-C motif ligand [CCL]-2, soluble intercellular adhesion molecule [sICAM]-1 and soluble vascular cell adhesion molecule [sVCAM]-1 concentration were measured. Individuals with CRP>10 mg/L and that were making use of anti-inflammatory medication were excluded from the analysis (final sample=254). An inflammatory score was calculated based on the sum of standardized values of the eleven inflammatory biomarkers. A multiple linear regression adjusted for age, gender and body mass index was used to test the association between each plasma inflammatory biomarkers and BHEI, as well as the association between the inflammatory score and BHEI and its components.
Results: the BHEI was inversely associated with plasma IL-6 concentration (p=0.014) and with the inflammatory score (p=0.026). When investigating the contribution of BHEI components to this association, total fruit and whole fruit components were inversely associated with the inflammatory score (p=0.037 and p=0.037, respectively) while saturated fat and solid fat, alcohol and sugar (SoFAAS) components were positively associated (p=0.001 and p=0.017, respectively).
Conclusion: higher BHEI values may have protective effects on inflammation in HS-SP population. Nutrition policies that target dietary quality as a whole and stimulate the adequate consumption of fruits, saturated fat and SoFAAS calories may prevent chronic low-grade inflammation-related diseases, such as cardiovascular disease, type 2 diabetes and cancer.
Marina Maintinguer Norde
University of Sao Paulo
Campinas, Sao Paulo, Brazil