Poster Topical Area: Biomarkers

Location: Auditorium

Poster Board Number: 146

P02-012 - Anemia and insomnia: a cross-sectional study and a meta-analysis

Sunday, Jun 10
8:00 AM – 6:00 PM

Objectives: Recent studies have investigated genes associated with insomnia complaints. Prevalence of insomnia due to poor iron deficiency has been widely explored in the pediatric population, but not well understood in adults. We examined whether adults with anemia have higher odds of having insomnia in a cross-sectional study and a meta-analysis.


Methods:
The cross-sectional study included 11,040 Chinese adults who participated in an ongoing cohort, the Kailuan Study. Anemia was defined as hemoglobin levels below 11 g/dL in women and 12 g/dL in men. Insomnia was assessed using the Chinese version of Athens Insomnia Scale (AIS). A total AIS score ≥6 was considered insomnia. The association between anemia and insomnia was assessed using a logistic regression model, adjusting for potential confounders such as age, sex, chronic disease status, and plasma C-reactive protein (CRP) concentrations. A meta-analysis was conducted using a random-effect model to pool results from our study and three previous publications on this topic. All of these studies used a cross-sectional study design.


Results:
Prevalence was 15.2% and 10.6% for anemia and insomnia, respectively. Overall, anemia was significantly associated with a greater risk of insomnia (adjusted odds ratio (OR): 1.32; 95% confidence interval (95% CI), 1.03-1.70 compared to individuals without anemia). Significant association persisted (adjusted OR: 1.68; 95% CI: 1.22-2.32). The meta-analysis results, including 20,560 participants, also identified a positive association between anemia and insomnia (pooled OR: 1.65; 95% CI: 1.29-2.11).


Conclusions:
Presence of anemia was significantly associated with higher likelihood of having insomnia.



Meta analysis of the association between anemia and insomnia

CoAuthors: Junjuan Li, M.D. – Kailuan General Hospital, Tangshan, China; Xiaodong Yuan, M.D. – Kailuan General Hospital, Tangshan, China ; Shuohua Chen, M.D. – Kailuan General Hospital, Tangshan, China ; Laura Murray-Kolb, Ph.D. – Pennsylvania State University, University Park, PA; Jiali Han, Ph.D. – Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis (JH); Shouling Wu, M.D. – Kailuan General Hospital, Tangshan, China ; Xiang Gao, M.D., Ph.D. – Pennsylvania State University, University Park, PA

Samantha Neumann

Student
Pennsylvania State University
Ambler, Pennsylvania