Poster Topical Area: Aging and Chronic Disease

Location: Auditorium

Poster Board Number: 22

P01-001 - Association of Fruits and Vegetable Consumption with Parkinsonism and its Progression in Older Adults

Sunday, Jun 10
8:00 AM – 6:00 PM

Objective: Half of the older population by 85 years of age develops mild parkinsonism, that is associated with disability and mortality. Previously, we have reported the association of healthy dietary patterns with reduced parkinsonism. In this study, we investigated whether two of the major food components of healthy diets, fruits and vegetables (i.e. berries, citrus fruits, green leafy, yellow and cruciferous vegetables) may be specifically associated with reduced parkinsonism.


Methods:
Participants (n=706) from the Rush Memory and Aging Project (ongoing longitudinal cohort), were clinically evaluated annually for 4.6(±3) years of follow-up using a 26-item modified version of United Parkinson's Disease Rating Scale (UPDRS) to assess four parkinsonian signs. Parkinsonism was defined by two or more parkinsonian signs present. A continuous measure of global parkinsonian score summarized the severity of parkinsonism. Fruits and vegetable intake was assessed using a validated food frequency questionnaire (FFQ) administered at the baseline. Participants with missing FFQ, Parkinson's disease at baseline or no follow-up UPDRS score were excluded from the study.


Results:
In separate proportional hazards models (adjusted for age, sex, smoking and total calories), the highest versus lowest quintiles of vegetable intakes were associated with reduced risk of incident parkinsonism (total vegetables (HR=0.65; 95%CI: 0.44-0.96, p trend= 0.03); green leafy (HR=0.57; 95%CI: 0.40-0.82, p trend= 0.02); cruciferous (HR=0.49; 95%CI: 0.30-0.82, p trend= 0.23) and yellow vegetables (HR=0.59; 95%CI: 0.40-.88, p trend= 0.04)). In separate adjusted linear mixed models, participants in the highest quintiles of intake of green leafy (β=-0.064, p=0.002) and cruciferous vegetables (β=-0.077, p=0.01) had slower progression of parkinsonism than those in the lowest quintiles. Berry intake (≥ 1 vs

Discussion:
Higher intake of vegetables and berries, but not other fruits may reduce the risk of parkinsonism and may slow its progression in older adults.




Funding Source: National Institute of Aging at National Institute of Health (R01AG054057) and Consolidated Anti-aging Foundation

CoAuthors: Yamin Wang – Rush University Medical Center; Aron Buchman – Rush University Medical Center; David Bennett – Rush University Medical Center; Martha Morris – Rush University Medical Center

Puja Agarwal

Post-doctoral research fellow
Rush University Medical Center
Chicago, Illinois