Poster Topical Area: Dietary Bioactive Components

Location: Hall D

Poster Board Number: 343

P08-085 - Hepatoprotective effects of a standardized pomegranate extract on high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is characterized by abnormal accumulation of triglycerides (TG) in liver cells. Despite the high prevalence of NAFLD in the general population of Western countries (20-30%), limited pharmacological agents have been approved for NAFLD treatment. Several studies support that natural products including dietary polyphenols show beneficial effects against NAFLD. Herein, we evaluated the hepatoprotective effects of a standardized pomegranate extract (PE) in mice with high fat diet induced NAFLD.

Methods: The 6 week old C57BL/6 male mice were divided into four groups (n=4) and fed with low fat diet (LFD; 10% kcal as fat), high fat diet (HFD; 45% kcal as fat), LFD with PE (1% w/w in diet), or HFD with PE (1% w/w in diet) for 12 weeks.

Results: Mice in both the LFD and HFD groups with PE had lower liver TG levels by 30.0% and 60.2%, as compared to the LFD and HFD group, respectively. In addition, HFD+PE group significantly reduced the mice body weight by 23.3% as compared to the HFD group. The HFD+PE group also had reduced liver lipids and liver non-esterified fatty acids levels by 41.8% and 70.8%, respectively, as compared to the HFD group.

Conclusions: These results suggest that PE may be beneficial for the amelioration of NAFLD warranting further evaluation of its hepaprotective effects. 

CoAuthors: Nicholas DaSilva – University of Rhode Island; Emliy Martell – University of Rhode Island; Hang Ma – University of Rhode Island; Angela Slitt – University of Rhode Island; Navindra Seeram – University of Rhode Island

Marisa Pfohl

University of Rhode Island
Kingston, Rhode Island