Poster Topical Area: Community and Public Health Nutrition

Location: Auditorium

Poster Board Number: 29

P06-008 - Does race affect gut hormones and adipokines in overweight and obese adults?

Monday, Jun 11
8:00 AM – 3:00 PM

Objective: Appetite hormones and adipokines are thought to influence energy homeostasis. However, there is limited research examining the effects of race on appetite hormones and adipokines. In this initial exploratory analysis, we seek to understand if race influences gut hormone and adipokine levels.

Methods: In a randomized controlled six-month supervised, controlled, exercise trial, 198 healthy adult participants with overweight or obesity were randomized to: 1) a no-exercise control group, 2) aerobic exercise at a dose of 8 kcal/kg of body weight per week (8 KKW), or 3) an exercise dose of 20 KKW. At baseline and day 170, blood was collected ~4 hours following a standard breakfast (190-kcal nutrition bar) and then ~1.5 hours following a lunch meal (postprandially). Blood samples were collected, processed, and analyzed per manufacturer’s instructions for the measurement of total ghrelin (RIA), PYY (RIA), GLP-1 (ELISA), and leptin (RIA). Only persons that self-identified as African American or White were used in this sub analysis. Overall race effects were examined.

Results: This sample (n=49 African American participants, n=108 White participants) was 71.3% female. Mean ± SD BMI was 31.7+4.7 kg/m2 (33.6 ± 4.9 kg/m2 among African American participants, 30.8 ± 4.4 kg/m2 among White participants). Mean age was 48.8+11.5 years (46.1 ± 10.3 y among African American participants, 50.0 ± 11.8 y among White participants). African American participants had lower ghrelin (-219.17 ± 76.15 pg/mL; p < 0.01), PYY (-13.39 ± 4.14 pg/mL; p < 0.01), and GLP-1 (-1.53 ± 0.72 pmol/L; p < 0.05) levels compared to white participants. Further, African American participants had higher leptin (12.81 ± 2.66 ng/mL; p < 0.01) levels compared to white participants.

Conclusions: Race affects gut hormone and adipokine levels. Our post-hoc analysis suggests that there is a need to further explore the impact of race on these circulating factors and potentially leads to an important new area of research.

Funding Source:

NIH R01 HL102166, P30 DK072476, and U54 GM104940

CoAuthors: Timothy Church – ACAP Health; Robbie Beyl – Pennington Biomedical Research Center; Candice Myers – Pennington Biomedical Research Center; Ursula White – Pennington Biomedical Research Center; Corby Martin – Pennington Biomedical Research Center

John W. Apolzan

Assistant Professor
Pennington Biomedical Research Center
Baton Rouge, Louisiana