Poster Topical Area: Neurobiology

Location: Hall D

Poster Board Number: 720

P16-018 - Cardiometabolic Risk Factors in Neurological Disorders

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Literature about the impact of neurological disorders (ND) on cardiometabolic status is inconsistent; some studies show a cardiometabolic protective effect, others show increased cardiometabolic risk. This cross-sectional study examined the cardiometabolic status and nutrition risk of participants with a ND compared to neurotypical controls (NT).

Methods: Twenty participants with NDs (64.2±10.9 years, 15 movement disorders, 5 acquired brain injury) and 11 NTs (71.9±5.1 years) were assessed for their cardiometabolic status after a 12-hour fast. The risk factors assessed were: 1) body mass index (BMI) >25 kg/m2; 2) systolic >130 mmHg and diastolic blood pressure >80 mmHg; 3) total cholesterol (TC) >200mg/dL; 4) high-density lipoprotein cholesterol (HDL-C) <40mg/dL; 5) low-density lipoprotein cholesterol (LDL-C) >100mg/dL; 6) triacylglycerol (TAG) >150mg/dL; 7) fasting glucose >100mg/dL. The Dietary Screening Tool (DST) assessed nutrition risk. Independent t-tests determined differences between ND and NT for each risk factor. Cohen's d was used to calculate effect size.

Results: There was no significant difference between NDs and NTs across risk factors. Mean BMI was 27.51±3.81 kg/m2 for NDs and 27.72±3.21 kg/m2 for NTs. Mean systolic blood pressure indicated stage 1 hypertension (ND=137.0±17.4 mmHg, NT=136.9±15.8 mmHg) for both groups. Mean TC and HDL-C were within normal limits. Mean LDL-C was 98.4±29.0 mg/dL (n=18, ND) vs. 113.3±32.8 mg/dL (n=7, NT). TAG was 118.6±60.9 mg/dL (n=19NDs) vs. 175.8±126.3 mg/dL (n=9NTs, d=-0.8). Mean glucose was 93.3±16.6 mg/dL and 102.1±19.0 mg/dL for ND and NT groups respectively (d=-0.5). 45% of NDs and 54.5% of NTs had >3 cardiometabolic risk factors. Thirteen NDs were at possible nutrition risk and 6 at nutrition risk. All NTs were at possible nutrition risk (n=8) or nutrition risk (n=3).

Conclusion: Results of the study reinforce the need for dietary modifications in ND and NT populations to curtail and prevent cardiometabolic disease. Those with an ND did not have more cardiometabolic risk factors in our sample than NTs. Large effect sizes indicated NDs may have more optimal glucose and TAG than NTs.




Funding Source: University of Rhode Island (URI)'s Spring 2016 Spark Funding Awards, Institute for Integrated Health and Innovation ($2,131.15). URI's Enhancement of Graduate Research Award, December 2016, ($1000).

CoAuthors: Leah Hurley – University of Rhode Island; Furong Xu, PhD – University of Rhode Island; Matthew Delmonico, PhD, MPH – University of Rhode Island; Leslie Mahler, PhD, CCC-SLP – University of Rhode Island; Ingrid Lofgren, PhD, MPH, RD – University of Rhode Island

Dara L. LoBuono

Graduate Research Assistant
Department of Nutrition and Food Sciences, University of Rhode Island
Kingston, Rhode Island