Poster Topical Area: Aging and Chronic Disease
Poster Board Number: 26
OBJECTIVE: To examine the influence of sugar-sweetened beverages (SSB) and their sugar content on hepatic fat content and liver enzymes (ALT, alanine aminotransferase; AST, aspartate aminotransferase; and GGT, gamma glutamyl transferase) in children with overweight/obesity.
METHODS: A total of 109 children (aged 10.6 ± 1.1 years, 54.1% girls) with overweight/obesity from Vitoria-Gasteiz (Spain) were included in the current study. Hepatic fat content was measured by magnetic resonance imaging and liver enzymes levels were obtained by fasting blood samples. Total and abdominal fat were measured by dual energy X-ray absorptiometry. Dietary intake was assessed by using two non-consecutive 24h-recalls and energy intake was obtained by the computer software program EasyDiet (©Biocentury, S.L.U). Participants were asked to report products brands in order to obtain the sugar content of SSB. Linear regression analyses were used to examine the associations of SSB and sugar from SSB with hepatic fat and liver enzymes. Statistical analysis were performed with SPSS version 20.0 and signiﬁcance (2-sided) was accepted when P < 0.05.
RESULTS: Both SSB consumption and sugar from SSB were positively associated with hepatic fat content regardless of sex, age, maternal educational level, energy intake and total and abdominal fat (β=0.236, p=0.012 and β=0.231, p=0.016, for SSB and sugar from SSB, respectively). Moreover, after further adjustment for total sugar intake these relationships were diminished but still remained significant (β=0.207, p=0.037 and β=0.200, p=0.047, for SSB and sugar from SSB, respectively). Furthermore,, AST, but not ALT or GGT, was positively associated with SSB consumption and its sugar content regardless of confounders (β=0.197, p=0.035 and β=0.209, p=0.027, for SSB and sugar from SSB, respectively).
CONCLUSIONS: The findings of the current study suggest that sugar sweetened beverages as well as their sugar content may negatively affect liver health in children with overweight/obesity. Therefore, nutritional education programs with a special focus on reducing the consumption of SSB should be promoted to improve dietary habits and prevent obesity and diet-related comorbidities later in life.
Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R)
"Fondos Estructurales de la Unión Europea (FEDER), Una manera de hacer Europa"
The University of the Basque Country (GIU14/21).
Spanish Ministry of Economy and Competitiveness (RYC 2010-05957; RYC-2011-09011)
Spanish Ministry of Education, Culture and Sports (FPU14/03329)
The Education Department of the Government of the Basque Country (PRE_2017_2_0224)
The Swedish Society of Medicine
Public University of Navarra
Aretxabaleta, Pais Vasco, Spain