Poster Topical Area: Neurobiology

Location: Hall D

Poster Board Number: 737

P16-035 - Effect of Low-Dose Wild Blueberry Powder and Extract in Maintenance of Episodic-Memory and Blood Pressure in Older Adults

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Chronic supplementation studies indicate flavonoid-rich interventions improve cognitive function in older adults. Typically, these studies have used limited sample size, acute/short duration, or limited doses. Here, we report a randomized, double blinded, placebo-controlled chronic intervention investigating two different wild blueberry interventions (a whole powder rich in fibers and flavonoids [WBP], and a purified extract devoid of fibers [WBE]) on cognitive performance in older adults. Both were supplemented with a proprietary formulation of L-Cysteine (Cys) and L-Glutathione (GSH) to stabilize and increase anthocyanin bioavailability.

One hundred and twenty two (112 completed) adults (65 - 80yrs) were allocated to a 6 month daily regimen of placebo, 450mg WBP + 45mg Cys + 5mg GSH (WBP500), 900mg WBP + 90mg Cys + 10mg GSH (WPB1000), or 100mg WBE + 10mg Cys + 1mg GSH (WBE111). Participants were tested at baseline, 3, and 6 months on a comprehensive task battery targeting episodic memory, working memory, executive function, and mood, as well as blood pressure and heart rate.

Linear Mixed Modelling analysis using baseline performance as a covariate found intervention significantly predicted delayed word recognition at the 3 month time point with simple contrast analysis revealing better WBE111 in comparison to placebo. Also at 3 months, intervention significantly predicted number of correctly recalled sequences on the Corsi Block task with simple contrast analysis revealing a trend towards better WBE111 in comparison to placebo. Across the 3 and 6 month time points, intervention significantly predicted systolic BP with simple contrast analysis revealing lower systolic BP following WBE111 in comparison to Placebo.

Results indicate WBE111 can facilitate better episodic memory performance following 3 months intervention and promote cardiovascular health over a 6 month period. Doses used were comparatively small compared to previous research and it is interesting to see effects even at such a low dose. Effects were not found for working memory, executive function, and mood. Research investigating the efficacy of interventions on these domains across a wider range of doses is currently in train.

Funding Source: Naturex-DBS

CoAuthors: Emilie Fromentin, PhD – Naturex-DBS; Nancy Cheng – The University of Reading; Claire Williams, PhD – The University of Reading

Adrian R. Whyte

Research Fellow
University of Reading
Kings Worthy, England, United Kingdom