Poster Topical Area: Neurobiology

Location: Hall D

Poster Board Number: 737

P16-035 - Effect of Low-Dose Wild Blueberry Powder and Extract in Maintenance of Episodic-Memory and Blood Pressure in Older Adults

Monday, Jun 11
8:00 AM – 3:00 PM

Objectives: Chronic supplementation studies indicate flavonoid-rich interventions improve cognitive function in older adults. Typically, these studies have used limited sample size, acute/short duration, or limited doses. Here, we report a randomized, double blinded, placebo-controlled chronic intervention investigating two different wild blueberry interventions (a whole powder rich in fibers and flavonoids [WBP], and a purified extract devoid of fibers [WBE]) on cognitive performance in older adults. Both were supplemented with a proprietary formulation of L-Cysteine (Cys) and L-Glutathione (GSH) to stabilize and increase anthocyanin bioavailability.




Methods:
One hundred and twenty two (112 completed) adults (65 - 80yrs) were allocated to a 6 month daily regimen of placebo, 450mg WBP + 45mg Cys + 5mg GSH (WBP500), 900mg WBP + 90mg Cys + 10mg GSH (WPB1000), or 100mg WBE + 10mg Cys + 1mg GSH (WBE111). Participants were tested at baseline, 3, and 6 months on a comprehensive task battery targeting episodic memory, working memory, executive function, and mood, as well as blood pressure and heart rate.




Results:
Linear Mixed Modelling analysis using baseline performance as a covariate found intervention significantly predicted delayed word recognition at the 3 month time point with simple contrast analysis revealing better WBE111 in comparison to placebo. Also at 3 months, intervention significantly predicted number of correctly recalled sequences on the Corsi Block task with simple contrast analysis revealing a trend towards better WBE111 in comparison to placebo. Across the 3 and 6 month time points, intervention significantly predicted systolic BP with simple contrast analysis revealing lower systolic BP following WBE111 in comparison to Placebo.




Conclusions:
Results indicate WBE111 can facilitate better episodic memory performance following 3 months intervention and promote cardiovascular health over a 6 month period. Doses used were comparatively small compared to previous research and it is interesting to see effects even at such a low dose. Effects were not found for working memory, executive function, and mood. Research investigating the efficacy of interventions on these domains across a wider range of doses is currently in train.




Funding Source: Naturex-DBS

CoAuthors: Emilie Fromentin, PhD – Naturex-DBS; Nancy Cheng – The University of Reading; Claire Williams, PhD – The University of Reading

Adrian R. Whyte

Research Fellow
University of Reading
Kings Worthy, England, United Kingdom